Type III protein secretion systems have specifically evolved to deliver bacterially encoded proteins into target eukaryotic cells. The core elements of this multi-protein machine are the envelope-associated needle complex, the inner membrane export apparatus, and a large cytoplasmic sorting platform. Here, we report a high-resolution in situ structure of the Salmonella Typhimurium type III secr...

Type III protein secretion machines have evolved to deliver bacterially encoded effector proteins into eukaryotic cells. Although electron microscopy has provided a detailed view of these machines in isolation or fixed samples, little is known about their organization in live bacteria. Here we report the visualization and characterization of the Salmonella type III secretion machine in live bac...

A generic machine learning model is proposed based on the theory of semantic primitives. It contains five components. Each of the component contains a set of primitives machine learning techniques. The input component contains primitives user initiative, system initiative, and system selection. The transformation component is composed of five primitives: generalization, specialization, integrat...

The SPring-8 storage ring control system has two kinds of access to the machine components, that is, an interactive operation and a periodic reading/monitoring operation. This paper describes the later. The machine status are periodically taken by processes on VME CPU(named the poller) and stored into shared memory. A process(collector client) running on the operator consoles cyclically collect...

Profess is a parallel program simulation tool designed to help application programmers in evaluating the performance of candidate implementations of their programs on a parallel machine. Users provide a high-level description of each program as structured compositions of known programming skeletons and program components. The system then uses a mixture of performance models and actual runs on t...

SLOOP-SMOK is a toolkit designed to improve the student design experience in an undergraduate machine organization course. The major goals were to improve the relevance of homework assignments to machine organization in general, and to emphasize some fundamental concepts of modern processors not easily addressed previously. SLOOP-SMOK has two components. The SLOOP Machine Organization Kit (SMOK...

In this thesis, a new synthesis algorithm for industrial controller programs is presented. Verification and synthesis are the two basic approaches to guarantee that a system is correct. While verification requires the programmer to provide both the specification and the implementation, synthesis automatically transforms the specification into an implementation that is correct by construction. T...

In this paper we present our work on the usage of lexical resources for the Machine Translation English and Malayalam. We describe a comparative performance between different Statistical Machine Translation (SMT) systems on top of phrase based SMT system as baseline. We explore different ways of utilizing lexical resources to improve the quality of English Malayalam statistical machine translat...