3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for the formation of major metabolites. NBP underwent extensive metabolism after an oral administration of 200 mg NBP and 23 metabolites were identified...

The biotransformation of taxol by human liver was investigated in vitro with microsomes isolated from adult and developing human tissues. In vitro, no metabolism was detected with kidney microsomes, whereas two metabolites were generated by liver microsomes. The most prominent metabolite, termed M5, corresponded to an hydroxylation at the C6 position on the taxane ring, while the other metaboli...

The French-American and British (FAB) classification of 62 consecutive cases of acute myeloid leukemia was undertaken. AML-M2 was the commonest FAB type (32.26%), followed by M1 and M4 (22.58% each), M5 (8.6%) and M6 and M7 (1.61% each), respectively. One of the patients was diagnosed as AML-MO (not a FAB type). The mean age of M1, M2, M3 and M5 cases was between 25 and 29 years, whereas in M4 ...

M5-branes wrapping a holomorphic curve in a Calabi-Yau manifold can be used to construct four-dimensional N = 1 gauge theories. In this paper we will consider M5-brane configurations corresponding to N = 2 theories broken to N = 1 by a superpotential for the adjoint scalar field. These M5-brane configurations can be obtained by lifting suitable intersecting brane configurations in type IIA, or ...

We show that the covariant effective action for M5-brane is a solution to the HamiltonJacobi (H-J) equations of 11-dimensional supergravity. The solution to the H-J equations reproduces the supergravity solution that represents the M2-M5 bound states. e-mail address : [email protected] e-mail address : [email protected]