The members of the integrin family of membrane glycoprotein heterodimer complexes function as cell surface receptors for adhesive proteins. We report here on the identification of two integrins on the surface of human platelets that bind to thrombospondin. When platelet membrane proteins are radiolabeled with 125I-lactoperoxidase, solubilized in n-octylglucoside, (Boehringer Mannheim Biochemica...

The disruption of the trade and investment activities multinational enterprises as a consequence Covid-19 pandemic has reinvigorated debate on configuration global value chains (GVCs) well risks challenges associated with offshoring. This article depicts how might affect GVC by driving trend toward more regional footprint in industries which resilience reliability are critical. Such shift would...

The sequences involved in the replication and packaging of transmissible gastroenteritis virus (TGEV) RNA have been studied. The structure of a TGEV defective interfering RNA of 9.7 kb (DI-C) was described previously (A. Mendez, C. Smerdou, A. Izeta, F. Gebauer, and L. Enjuanes, Virology 217: 495-507, 1996), and a cDNA with the information to encode DI-C RNA was cloned under the control of the ...

Assuming three-neutrino mixing, we study the capabilities of very long baseline neutrino oscillation experiments to verify and test the MSW effect and to measure the lepton mixing angle θ13. We suppose that intense neutrino and antineutrino beams will become available in so–called neutrino factories. We find that the most promising and statistically significant results can be obtained by studyi...

Purpose: Multimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin αvβ3 expression. Here, we compared the in vitro and in vivo behavior of three different Ga-68-labeled multimeric Fusarinine C-RGD (FSC-RGD) conjugates, whereby RGD was coupled directly, via a succinic acid or PEG linker (FSC(RGDfE)3, FSC(succ-RGD)3, FSC(MalRGD)3). The positron emission tomogra...

The Mode I and II Interlaminar Fracture Toughness (IFT) of Vectran/Epoxy composite material were investigated using the Double Cantilever Beam (DCB) 4 End Notched Flexure (4ENF) methods, respectively. Due to relatively low compressive strength Vectran (<10% its tensile properties), specimens hybridised by over wrapping with T800s/M21 prevent failure during testing. Experimental results then sim...

Integrin Otv~3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components. Here, we demonstrate that in addition to the recognition of ECM components, ave3 can interact with the neural cell adhesion molecule L1-CAM; a member of the immunoglobulin superfamily (IgSF). M21 melanoma cells displayed significant Ca++-dependent adhesion and s...

The present study experimentally investigates the mechanical response of T700/M21 Carbon Fibre Reinforced Polymers subjected to coupled shear and transverse tension at intermediate strain rates ranging from 10−3 15 s−1. Off-axis specimens with oblique tabs are used for various tests. Moreover, specimen aspect ratio is quite low, since dynamic tests performed in this study. axial stress–strain c...