Tissueand organ-specific factors may be important in the regulation of cytotoxic lymphocytes. We therefore examined the ability of human alveolar macrophages (AMs) to alter the tumoricidal function of lymphokine-activated killer cells (LAK cells). AMs, obtained by bronchoalveolar lavage from healthy volunteers, or peripheral blood monocytes were added to a standard 4-h chromium release LAK assa...

If the interplay between caspase proteases and mitochondria decide the fate of the cell during apoptosis, they may constitute useful molecular targets for novel drug design. We have shown that photoactivated merocyanine 540 (pMC540) triggers caspase-mediated apoptosis in HL60 leukemia and M14 melanoma cells. Because pMC540 is a mixture of photoproducts, we set out to purify the biologically act...

Tissue- and organ-specific factors may be important in the regulation of cytotoxic lymphocytes. We therefore examined the ability of human alveolar macrophages (AMs) to alter the tumoricidal function of lymphokine-activated killer cells (LAK cells). AMs, obtained by bronchoalveolar lavage from healthy volunteers, or peripheral blood monocytes were added to a standard 4-h chromium release LAK as...

We present a CCD $VI$ photometric study of the globular cluster M14. Particular attention is given to variable stars. This allowed new classifications and membership considerations. New variables are reported; 3 RRc, 18 SR 1 SX Phe. The Fourier decomposition RR Lyrae light curves lead mean metallicity [Fe/H]$_{\rm ZW}= -1.3 \pm 0.2$. Several independent methods yield distance $9.36 0.16$ kpc. A...

High-entropy alloys (HEAs) are based on solid solutions which characterized by chemical short-range ordering (CSRO), but there is no accurate structural tool to address CSRO characteristic, obstacles precise composition design for HEAs. In this study, the cluster-plus-glue-atoms model, law of Al-TMs (TMs, transition metals) HEAs with BCC and FCC structures was revealed. structure, five elements...

Abstract Background We aimed to assess the gene expression profiles of uninflamed small bowels in patients with Crohn’s disease (CD) identify its accompanying molecular alterations. Methods performed RNA sequencing bowel tissues obtained from 70 ileal CD, and 9 colon cancer (non-CD controls) during resection. Differentially expressed (DEG) analyses were using DESeq2. Gene set enrichment, correl...

The use of slip-critical connections is very common in the design critical steel structures and seen as an effective way to transfer force conditions dynamic loading. limit state connection occurs when calculated shear stress reached, which depends on friction coefficient contact planes value clamping force, equal bolt tension stress. In order ensure necessary tensioning it know tightening coef...