نتایج جستجو برای: m13 pix
تعداد نتایج: 2521 فیلتر نتایج به سال:
Based on MAGIC observations from June and July 2007, we present upper limits to the E > 140 GeV emission from the globular cluster M13. Those limits allow us to constrain the population of millisecond pulsars within M13 and to test models for acceleration of leptons inside their magnetospheres and/or surrounding. We conclude that in M13 either millisecond pulsars are fewer than expected or they...
Commonly used in biotechnology applications, filamentous M13 phage are non-lytic viruses that infect E. coli and other bacteria, with the potential to promote horizontal gene transfer in natural populations with synthetic biology implications for engineering community systems. Using the E. coli strain TG1, we have investigated how a selective pressure involving elevated levels of toxic chromate...
The Rho family of GTPases plays an important role in coordinating dynamic changes in the cell migration machinery after integrin engagement with the extracellular matrix. Rho GTPases are activated by guanine nucleotide exchange factors (GEFs) and negatively regulated by GTPase-activating proteins (GAPs). However, the mechanisms by which GEFs and GAPs are spatially and temporally regulated are p...
Branching morphogenesis is a fundamental process in the development of the kidney. This process gives rise to a network of ducts, which form the collecting system. Defective branching can lead to a multitude of kidney disorders including agenesis and reduced nephron number. The formation of branching tubules involves changes in cell shape, cell motility, and reorganization of the cytoskeleton. ...
Increased permeability of blood vessels is an important component of inflammation, but in some circumstances it contributes to tissue injury and organ failure. Previous work showed that p21-activated kinase (PAK) is a critical regulator of endothelial cell-cell junctions through effects on myosin light chain phosphorylation and cell contractility. We now show that blocking PAK function inhibits...
We have obtained 782 real spectra and used them as inputs for 6700 automatic crosscorrelation runs to investigate GAIA potential in terms of radial velocity accuracy. We have explored the dispersions 0.25, 0.5, 1 and 2 Å/pix over the 8490–8740 Å GAIA range. We have investigated late-F to early-M stars (constituting the vast majority of GAIA targets), slowly rotating (< Vrot sin i > = 4 km sec )...
Adenoviral vectors based on adenovirus type 35 (rAd35) have the advantage of low natural vector immunity and induce strong, insert-specific T- and B-cell responses, making them prime-candidate vaccine carriers. However, severe vector-genome instability of E1-deleted rAd35 vectors was observed, hampering universal use. The instability of E1-deleted rAd35 vector proved to be caused by low pIX exp...
THE employment of tar in dermatology has a long history. According to Hebra (1868), Theophrastus, Dioscorides and Pliny advocated its use in the treatment of diseases of the skin. For many centuries this treatment fell into disfavour, partly on account of the general acceptance of Galen's " acrimonia sanguinis " theory ofthe causation ofskin disease which discouraged the use oflocal application...
Cloning of DNA fragments in phage M13 is a routine procedure in DNA sequence determination. A simple procedure for the determination of DNA fragment orientation has been described earlier (1). Here we introduce a modification of this procedure which allows the simultaneous determination of DNA fragment orientation and size. Procedure: Single-stranded M13 DNAs (1, about lpg) were mixed in 5ul of...
A new cloning strategy is described which utilizes direct selection of recombinants for shotgun sequencing in the filamentous bacteriophage M13. Direct selection is accomplished by insertional inactivation of the M13 gene X protein, a powerful inhibitor of phage-specific DNA synthesis when overproduced. An extra copy of gene X was inserted into the intergenic region of M13 and placed under the ...
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