The effect of whole-body irradiation on rat thymus, 3 differ ent mouse lymphosarcomas, and a mouse myeloid leukemia were studied. In thymus, myeloid leukemia, and C57BL-lymphosarcoma, the inhibition of nuclear adenosine-5'-triphosphate (ATP) synthesis and mitochondrial oxidative phosphorylation is demonstrated within a few hr after irradiation. The inhibition of nuclear ATP synthesis precedes t...

Among the 100 tumors that have been induced in this laboratory during the past year by the injection of 1: 2 : 5: 6-dibenzanthracene into mice were three lymphosarcomata. Lesions of the lymphatic system, lymphoid leukemia and lymphosarcoma have not occurred as a genetic factor in the untreated mice of the pure inbred strains used, although apparently such strains are not uncommon or difficult t...

Hepatic and splenic microsomal electron transport system function, microsomal heme oxygenase activity, and microsomal drug metabolism have been examined in male Wistar rats bearing Murphy-Sturm lymphosarcoma 2 to 15 days following i.m. tumor transplantation. Hepatic microsomal cytochrome P450 and NADPH-cytochrome c reducÃ-ase activity decreased significantly [cytochrome P-450 nadir was 0.49 ± ...

Among 1,000 selected compounds and antibiotics tested against all or portions of the tmnor spectrum (33 tumors), cytoxan was the most effective, having a marked inhibitory to complete inhibitory effect on ~6 out of 38 tumors. Cytoxan (50 mg /kg /day for mice; ~5 m g / k g / d a y for rats) had a destructive effect on well established 7-day-old Sarcoma T5~41, Carcinoma 10~5, Lewis bladder carcin...

Lits, Kirschbaum, and Strong (2), using a transplantable lymphosarcoma in mice, found that colchicine would apparently cause complete re gression in some animals but that recurrence in evitably occurred. One of the most successful at tempts in treating a transplanted lymphosarcoma was reported by Heilman and Kendall (3). They showed that Compound E (ll-dehydro-17-hydroxycorticosterone) produced...

The circulation of lymphoid cells in thoracic duct lymph of rats with lymphosarcoma (LSA) and leukemia was investi gated. Rats were inoculated with. Murphy-Sturm lymphosar coma either by the i.m. route, which yields a localized tumorsimulating LSA, or by the i.v. route, which results in lymphatic leukemia (LL). Thoracic duct fistulae were estab lished in four groups of rats, including untreated...

2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immun...

Cell surface immunoglobulin, complement receptor, and spontaneous rosette formation with sheep erythrocytes were investigated in 43 patients with malignant lymphoma, including 13 with lymphosarcoma cell leukemia, and in 59 patients with chronic lymphocytic leukemia. The quantity of immunoglobulin on the lymphocyte surface was estimated from the intensity of fluorescent staining with fluorescein...