Global Program to Eliminate Lymphatic Filariasis (GPELF) guidelines call for using filarial antigen testing to identify endemic areas that require mass drug administration (MDA) and for post-MDA surveillance. We compared a new filarial antigen test (the Alere Filariasis Test Strip) with the reference BinaxNOW Filariasis card test that has been used by the GPELF for more than 10 years. Laborator...

n engl j med 366;13 nejm.org march 29, 2012 1169 Wuchereria bancrofti (and, in Asia, Brugia malayi and B. timori), which is transmitted by mosquitoes. The second principal cause is podoconiosis. Lymphatic filariasis is endemic in some 72 countries throughout the tropics (see map), and an estimated 1.39 billion people live in areas of risk.1 An estimated 40 million people have stigmatizing and d...

A successful experience of lymphatic filariasis control in the Republic of Korea is briefly reviewed. Filariasis in the Republic of Korea was exclusively caused by infection with Brugia malayi. Over the past several decades from the 1950s to 2006, many investigators exerted their efforts to detection, treatment, and follow-up of filariasis patients in endemic areas, and to control filariasis. M...

Lymphatic filariasis has been targeted by the World Health Organization for elimination by the year 2020. Malayan filariasis, caused by Brugia malayi, is endemic in southern Thailand where domestic cats serve as a major reservoir host. However, in nature, domestic cats also carry B. pahangi infection. In addition to chemotherapy and vector control, control in reservoir hosts is necessary to ach...

Lymphatic filariasis is a neglected parasitic disease that leading cause of long-term disability. Information obtained from genome sequencing filarial worm can help us identify systems in the are likely to be useful for novel drug design. Brugia ( B .) malayi still only lymphatic-dwelling parasite with nearly complete, fully annotated, and published genome. However, most previous studies were b...

Lymphatic filariasis is a major tropical disease caused by the mosquito-borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Vaccines against filariasis must generate immunity to the infective mosquito-derived third-stage larva (L3) without accentuating immunopathogenic responses to lymphati...

Lymphatic filariasis is the most common cause of acquired lymphedema worldwide (Szuba and Rockson, 1998). It is endemic to tropical and subtropical regions, and its effects are devastating. With over 100 million infected persons, it ranks second only to leprosy as the leading cause of permanent and long-term disability. Wuchereria bancrofti is the etiologic agent in 90% of cases. There is a dea...

Lymphatic filariasis (LF), also known as elephantiasis, is a major disease of tropical and subtropical regions worldwide. LF is endemic in 80 countries, it is estimated that 120 million people are infected, with one third of them suffering from chronic manifestation of the disease. One billion more individuals are at risk of acquiring the infection [1]. Lymphatic filariasis is a mosquito-borne ...