Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse involving multiorgan failure, complex interaction of various drugs, human herpesvirus reactivation immune abnormalities suggested as the aetiology. We herein present case 70-year-old man one-week history fever, facial oedema, erythematous macules purpura on his trunk extremities. He had anti-TIF1γ antibo...

The interpretation of low-temperature thermochronology (LTT) data in magmatic and metallogenic provinces requires a knowledge the geothermal field through time. There, challenge is differentiating rapid cooling following transient perturbations geotherms (reheating) from exhumational induced by erosion during tectonic uplift or normal faulting. Takab Range Complex (NW Iran) basement-cored range...

Tetrazepam is a benzodiazepine that is widely used in Spain as a muscle relaxant, with occasional cutaneous side effects. We report a patient who developed a generalized pruriginous cutaneous reaction compatible with acute generalized exanthematous pustulosis (AGEP) due to tetrazepam. Patch tests with bromazepam, diazepam, and tetrazepam were negative at 48 and 72 hours; however, the tetrazepam...

Theory suggests that the structure of evolutionary history represented in a species community may affect its functioning, but phylogenetic diversity metrics do not allow for the identification of major differences in this structure. Here we propose a new metric, ELDERness (for Evolutionary Legacy of DivERsity) to estimate evolutionary branching patterns within communities by fitting a polynomia...

The efficacy of intravenous choline citrate infusions was investigated in 34 patients with multiple sclerosis (MS) by clinical evaluation and by monitoring of lymphocyte proliferation in vitro against fragments of myelin basic protein (MOG-35-55, MBP15-31, PLP 39-15) over a period of 12 weeks. Patients have been diagnosed with MS at least one year before entering the study and suffered from mil...

We present the type theory LTT, intended to form a basis for typed target languages, providing an internal notion of logical proposition and proof. The inclusion of explicit proofs allows the type system to guarantee properties that would otherwise be incompatible with decidable type checking. LTT also provides linear facilities for tracking ephemeral properties that hold only for certain progr...

We present a programme of research for pluralist formalisations — formalisations that involve proving results in more than one foundation. A foundation consists of two parts: a logical part that provides a notion of inference, and a non-logical part that provides the entities to be reasoned about. A logic-enriched type theory (LTT) is a formal system composed of such two separate parts. We show...

ADRs: adverse drug reactions LTT: lymphocyte transformation test MDH: multiple drug hypersensitivity MDHS: multiple drug hypersensitivity syndrome MP: Mycoplasma pneumoniae PA: particle agglutination SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis Tregs: regulatory T cells INTRODUCTION Many adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS)/toxic epidermal necr...

Objectives: Minimal hepatic encephalopathy (MHE) is a preclinical stage of overt hepatic encephalopathy (OHE). All MHE therapies modify gut microflora but consensus regarding MHE treatment is lacking. The aim of this study is to determine the effect of probiotic is reversing MHE in cirrhotic patients. Patients and Methods: A total of 58 cirrhotic patients were enrolled (44 males, 14 females) ag...

Freshwater habitats make up only ∼0.01% of available aquatic habitat and yet harbor 40% of all fish species, whereas marine habitats comprise >99% of available aquatic habitat and have only 60% of fish species. One possible explanation for this pattern is that diversification rates are higher in freshwater habitats than in marine habitats. We investigated diversification in marine and freshwate...