a quantitative structure–activity relationship (qsar) study is suggested for the prediction of biological activity (pic 50 ) of 3, 4-dihydropyrido [3 ,2-d] pyrimidone derivatives as p38 inhibitors. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of principal component analysis (pca) and least square support vector mac...

conclusions our findings show that, at provincial levels, a complex set of known/unknown influencing factors affect individuals’ assessments of their own health quality. understanding these patterns of srh and ls could be useful for better health policy and more targeted studies in this field. background self-rated health (srh) and life satisfaction (ls) are of increasing interest to medical re...

BACKGROUND Pulmonary complications are the most common cause of death and morbidity in systemic sclerosis (SSc). The forced oscillation technique (FOT) offers a simple and detailed approach to investigate the mechanical properties of the respiratory system. We hypothesized that SSc may introduce changes in the resistive and reactive properties of the respiratory system, and that FOT may help th...

BACKGROUND/AIMS Smooth muscle cells may dedifferentiate into the synthetic phenotype and promote atherosclerosis. Here, we explored the role of myoendothelial gap junctions in phenotypic switching of human coronary artery smooth muscle cells (HCASMCs) co-cultured with human coronary artery endothelial cells (HCAECs) exposed to shear stress. METHODS HCASMCs and HCAECs were seeded on opposite s...

EDITORIAL article Front. Hum. Dyn., 21 June 2021Sec. Refugees and Conflict Volume 3 - 2021 | https://doi.org/10.3389/fhumd.2021.720484

It has recently been demonstrated that selective inhibition of both neuronal constitutive and inducible nitric oxide synthases (ncNOS and iNOS) is neuroprotective in a model of dynorphin (Dyn) A(1-17)-induced spinal cord injury. In the present study, various methods including the conversion of 3H-L-arginine to 3H-citrulline, immunohistochemistry and in situ hybridization are employed to determi...

Little is understood about endothelial cell (EC) responses to high flow, which mediate adaptive outward remodeling as well as cerebral aneurysm development. Opposite EC behaviors have been reported in vivo including cell loss during aneurysm initiation and cell proliferation during adaptive outward remodeling. This study aims at elucidating the EC growth response to elevated wall shear stress (...

A certain systolic assistance in Demand Dynamic Cardiomyoplasty (DDCMP) has been suggested. We here evaluate relations between muscular properties of Latissimus Dorsi wrap (LDW) and systolic function using the doppler flow wire combined with LDW mechanogram. On the basis of previous study, we divided the patients in two groups on the time between intervention and start of demand protocol (group...

OBJECTIVE To determine whether the beta blocker esmolol reduces coronary artery wall stress more than the short acting dihydropyridine calcium antagonist nicardipine. DESIGN Randomised double blind placebo controlled trial. SETTING Tertiary cardiology centre. PATIENTS Patients with coronary artery disease. INTERVENTIONS 20 patients were randomised double blind to an infusion of nicardip...

The purpose of this study was to determine the reliability of three normalization methods for analyzing hip abductor activation during rehabilitation exercises. Thirteen healthy subjects performed three open kinetic chain and three closed kinetic chain hip abductor exercises. Surface EMG activity for the gluteus medius was collected during each exercise and normalized based on a maximum volunta...