OBJECTIVE To estimate the impact of adding low-molecular-weight heparin (LMWH) or unfractionated heparin to low-dose aspirin started ≤ 16 weeks' gestation on the prevalence of pre-eclampsia (PE) and the delivery of a small-for-gestational-age (SGA) neonate. METHODS A systematic review and meta-analysis of randomized controlled trials (RCTs) was performed by searching the medical databases Pub...

We performed a meta-analysis to evaluate the risk of venous thromboembolism (VTE) in pregnant women with essential thrombocythemia. Twenty-one trials and 756 pregnancies met inclusion criteria. The absolute VTE risk in the antepartum period is not above a threshold where low-molecular-weight heparin (LMWH) prophylaxis is clearly indicated or below a threshold where LMWH should be withheld (2.5%...

Fluorescence and stopped flow methods were used to compare clinically used heparins with regard to their ability to bind to antithrombin and to accelerate the inactivation of factor Xa. Titration of antithrombin with both low molecular weight heparin (LMWH) (enoxaparin, fragmin and ardeparin) and unfractionated heparin (UFH) produced an equivalent fluorescence increase and indicates similar aff...

Main results The 7-day LMWH group had lower incidences of the primary and secondary efficacy endpoints than did the GCS group (Table). The 7-day LMWH and GCS groups did not differ for either safety endpoint. Results for the 14-day LMWH group are not presented because the trial was stopped prematurely for this group based on safety concerns. Conclusion Low-molecular-weight heparin for 7 days was...

Background: Unfractionated heparin (UFH) and low-molecular-weight (LMWH) are commonly used anticoagulants for the management of arterial venous thromboses. However, it is crucial to be aware that LMWH can, in rare cases, lead a dangerous complication known as heparin-induced thrombocytopenia (HIT). The objective this study was evaluate pharmacovigilance clinical features HIT associated with LMW...

Heparins, unfractionated or low molecular weight, are permanently in the spotlight of both clinical indications and laboratory monitoring. An accurate drug dosage is necessary for an efficient safe therapy. The one-stage kinetic anti-FXa assays most widely universally used with full automation large series, without needing exogenous antithrombin. WHO International Standards available UFH LMWH, ...

In 2020 declared the COVID-19 pandemic. A new SARS-Cov-2 betacoronavirus transmitted through respiratory secretions of infected people, causing lesions in pulmonary microvasculature, endothelial activation, massive release pro-inflammatory substances "cytokine storm", which lead to a procoagulant state and on it will depend development serious disease. The management coagulopathy induced by ent...

Low-molecular-weight heparins (LMWH) have been shown to be efficient in the treatment of inflammatory bowel disease (IBD). Parenteral heparin therapy, however, may cause hemorrhagic adverse effects. To reduce this risk, epithelial LMWH delivery in combination with a system ensuring selective drug release to the inflamed tissue was tested here. Enoxaparin loaded microspheres (MS) were administer...

Low molecular weight heparins (LMWHs) are the standard agents used for antithrombotic therapy and prophylaxis. Despite their widespread use, reports about adverse effects from LMWHs are very scarce. Heparin-induced skin necrosis at the injection site is a rare adverse effect, more commonly associated with unfractionated heparin (UFH) rather than with LMWH, while its mechanism remains unclear. T...

The aim of the study was to establish the importance of low molecular weight heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia. This retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb University Hospital Center in the period from January 2014 to January 2015. Fifty-seven women were treated and 13 women were ...