tramadol is used in treatment of moderate to severe pain. nowadays tramadol overdose is one of the common emergencies. naloxone is an antagonist which is used as a first step of treatment in these patients. this study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. a number of 124 patients with the diagnosis of tramadol overdose were divided to receive low-do...

The concept of hormesis, or low-dose U-shaped responses, is now well established in toxicology and pharmacology but requires development in medicine and therapeutics. In doing so, care must be taken to not confuse metaphorical and chemical uses of the term hormesis. Low dose, continuous adaptive responses are fundamentally different than conventional pharmacology, and they may improve the scien...

The effectiveness of child-resistant closures, required under the Poison Prevention Packaging Act of 1970, in reducing the incidence of accidental ingestion of aspirin and aspirin-containing products among children less than 5 years of age has been investigated. Data from Poison Control Centers and the National Center for Health Statistics were analyzed to determine the ingestion level before a...

purpose: to evaluate tear film status and refractive conditions during and one month after treatment of acne vulgaris with isotretinoin (accutane). methods: this prospective study was performed on 26 eyes of 13 known cases of acne vulgaris. all cases were referred by a dermatologist and were candidates for low dose isotretinoin (0.5 mg/kg). full anterior and posterior segment examination and ob...

recombinant human erythropoietin (rh-epo) is known to accelerate erythropoiesis in preterm infants. the purpose of this study was to compare the effectiveness of early treatment with two doses of rh-epo (high vs. low dose) in the management of anemia of prematurity. twenty preterm infants with hematocrit (hct) < 30% when infant’s age was between 2 to 3 weeks after birth or hct <25% when infant’...