We develop the original Life Origination Hydrate Hypothesis (LOH-hypothesis) of repeated origination of the living matter simplest elements (LMSEs) from CH4 (or other CH4-hydrocarbon), niter, and phosphate under the Earth's surface or seabed within honeycomb structures of hydrocarbon hydrates. The LOH-hypothesis gives a new possibility for understanding the monochirality of nucleic acids. A PC ...

Late-onset hypogonadism (LOH) in aging men is a clinical and biochemical syndrome caused by an age-related decline in testosterone. Despite published in guidelines and recommendations, uncertainty surrounds the profile of clinical symptoms as well as the biochemical threshold of diagnosis. The only evidence-based treatment of late-onset hypogonadism is testosterone replacement therapy. The actu...

Application The Needs and Benefits of Applying Textual Data Mining within the Product Development Process Rakesh Menon1,∗,†, Loh Han Tong1,2, S. Sathiyakeerthi2, Aarnout Brombacher1,3 and Christopher Leong4 1Design Technology Institute, 10 Kent Ridge Crescent, Singapore 119260 2Department of Mechanical Engineering, National University of Singapore, Singapore 119260 3Technische Universitait Eind...

We introduce two new variance estimation procedures by using non-overlapping and overlapping blocks, respectively. The non-overlapping block (NOB) estimator can be viewed as the limit of the thinned block bootstrap (TBB) estimator recently proposed in Guan and Loh (2007), by letting the number of thinned processes and bootstrap samples therein both increase to infinity. Compared to the latter, ...

Exposures to chloroform via showering, bathing, and swimming have been characterized much better since 1999, and these studies show that blood levels are usually higher via these routes than via drinking chlorinated water (Xu & Weisel, 2005; Caro & Gallego, 2007; Zwiener et al., 2007). Chloroform exposure has also been documented in various occupations (Ruder, 2006) and in microenvironments, su...

A natural first generation hybrid fungus shows interspecific heterozygosity. The nuclear condition of a rare natural hybrid between two taxa of the Heterobasidion complex is investigated. Heterobasidion species are known to be either homokaryotic (haploid) or heterokaryotic (n+n), but heterokaryons are made up of both homokaryotic and heterokaryotic sectors. The natural hybrid appears to be eit...

Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving independently of each other, a phenomenon termed the Meselson effect. We apply a population genomics approach to examine this effect in an important human pathogen, Trypanosoma brucei gambi...

We describe a genetic instability found in natural wine yeasts but not in the common laboratory strains of Saccharomyces cerevisiae. Spontaneous cyh2(R)/cyh2(R) mutants resistant to high levels of cycloheximide can be directly isolated from cyh2(S)/cyh2(S) wine yeasts. Heterozygous cyh2(R)/cyh2(S) hybrid clones vary in genetic instability as measured by loss of heterozygosity at cyh2. There wer...