نتایج جستجو برای: long chain acyl coa synthetase
تعداد نتایج: 1084410 فیلتر نتایج به سال:
The draft genome of the diatom Thalassiosira pseudonana was searched for DNA sequences showing homology with long-chain acyl-coenzyme A synthetases (LACSs), since the corresponding enzyme may play a key role in the accumulation of health-beneficial polyunsaturated fatty acids (PUFAs) in triacylglycerol. Among the candidate genes identified, an open reading frame named TplacsA was found to be fu...
We have used radio-high pressure liquid chromatography to study the acyl-CoA ester intermediates and the acylcarnitines formed during mitochondrial fatty acid oxidation. During oxidation of [U-14C]hexadecanoate by normal human fibroblast mitochondria, only the saturated acyl-CoA and acylcarnitine esters can be detected, supporting the concept that the acyl-CoA dehydrogenase step is rate-limitin...
Cell-free extracts of the unicellular green alga, Chlnmydomonas reinhardi, catalyze the incorporation of acetyl-CoA and malonyl-CoA into long chain fatty acids. The fatty acid synthetase is dependent on added acyl carrier protein for activity, regardless if the cells are grown in the light or in the dark. The major products formed from acetyl-CoA and malonyl-CoA by cells in the light period of ...
The synthesis of long chain fatty acids from acetate in mammalian, extramitochondrial ("solu-ble") systems requires three enzymatic steps: 1) the activation of acetate to form acetyl-coenzyme A (acetyl-CoA), 2) the carboxylation of acetyl-CoA by the enzyme acetyl-CoA carboxylase to form malonyl-coenzyme A (malonyl-CoA), and 3) the subsequent complex series of serial condensations of malonyl-CoA...
Over the last years acylcarnitines have emerged as important biomarkers for the diagnosis of mitochondrial fatty acid beta-oxidation (mFAO) and branched-chain amino acid oxidation disorders assuming they reflect the potentially toxic acyl-CoA species, accumulating intramitochondrially upstream of the enzyme block. However, the origin of these intermediates still remains poorly understood. A pos...
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