BACKGROUND Hypothermia is associated with increased morbidity and mortality rates. Preterm infants frequently have hypothermia when they are admitted to the NICU, but there is no data on the occurrence of hypothermia during the first hours after admission. OBJECTIVE To investigate the occurrence of hypothermia in preterm infants in the first three hours of admission and to identify risk facto...

IN THE PAST DECADE hypothermia has been a subject of intense experimental and clinical study.'-6 After initial experiences showed its severe limitations for intracardiac surgery, many technics of hypothermia were gladly discarded as pump-oxygenators were developed. Subsequently, the combination of hypothermia and extracorporeal circulation has permitted degrees of hypothermia previously incompa...

Adenosine can induce hypothermia, as previously demonstrated for adenosine A1 receptor (A1AR) agonists. Here we use the potent, specific A3AR agonists MRS5698, MRS5841, and MRS5980 to show that adenosine also induces hypothermia via the A3AR. The hypothermic effect of A3AR agonists is independent of A1AR activation, as the effect was fully intact in mice lacking A1AR but abolished in mice lacki...

Adenosine can induce hypothermia, as previously demonstrated for adenosine A1 receptor (A1AR) agonists. Here we use the potent, specific A3AR agonists MRS5698, MRS5841, and MRS5980 to show that adenosine also induces hypothermia via theA3AR. The hypothermic effect of A3ARagonists is independent of A1AR activation, as the effect was fully intact in mice lacking A1AR but abolished in mice lacking...

OBJECTIVE To review human thermoregulation and the pathophysiology and management of induced and accidental hypothermia. DATA SOURCES A review of studies reported over ten years from 1990 to 2000 and identified through a MEDLINE search of the English-language literature on thermoregulation and induced and accidental hypothermia. SUMMARY OF REVIEW Hypothermia is defined as a core temperature...

The complications of therapeutic hypothermia sometimes undermine its clinical effects. In this study we investigated the efficacy and safety of therapeutic hypothermia based on analysis of 20 severe head injury cases from 6 institutions treated with therapeutic hypothermia in 1999. The twenty patients with severe head injury were enrolled prospectively based on the following indications; Glasgo...

STROKE is, according to the World Health Organization (10), the third most common cause of death in the developed countries, exceeded only by coronary heart disease and cancer. Annually, 15 million people worldwide suffer a stroke. Of these 15 million people, 5.5 million die and 5 million are left permanently disabled, placing a burden on family and community. The incidence of stroke is declini...

BACKGROUND Neonatal hypothermia remains a common problem and is related to elevated morbidities and mortality. However, the long-term neurodevelopmental effects of admission hypothermia are still unknown. This study attempted to determine the short-term and long-term consequences of admission hypothermia in VLBW preterm infants. STUDY DESIGN This retrospective study measured the incidence and...

STROKE is, according to the World Health Organization (10), the third most common cause of death in the developed countries, exceeded only by coronary heart disease and cancer. Annually, 15 million people worldwide suffer a stroke. Of these 15 million people, 5.5 million die and 5 million are left permanently disabled, placing a burden on family and community. The incidence of stroke is declini...