A 67-yr-old female patient gave a history of allergy to lignocaine. When she was challenge-tested with the intradermal injection of 0.5% bupivacaine 0.2ml she had a systemic reaction. This reaction was accompanied by a decrease in the concentration of complement C4 in the plasma, which indicated that the reaction was immunologically-mediated. This is the first report of allergy to a local anaes...

A 35-year-old female had severe anaphylactoid reactions to pnlocaine and lignocaine on separate occasions Intradermal testing was positive to serial dilutions of both drugs and negative to bupivacaine, which was subsequently used uneventfully While intradermal testing for local anaesthetic allergy has limited application it would appear that when such te*ts are positive in high dilution they ma...

BACKGROUNDS Various methods were defined to prepare patients for the pilonidal sinus surgery including local, spinal, and general anesthesia. But there is no powerful evidence to differ these procedures. Therefore, in the current study, we compared local and general anesthesia in the pilonidal sinus surgery. METHODS & MATERIAL in this clinical trial (IRCT201312031786N5) study 60 patients with...

In 1884 a young Viennese doctor, Carl Koller, was the first to recognise the significance of the topical effects of the alkaloid cocaine and thus introduced drug-induced local anaesthesia to clinical practice. Most subsequent development took place in Europe and the United States, with British interest not becoming apparent for over twenty years. This is surprising because a number of doctors w...

local anesthesia forms the major part of pain-control techniques in dentistry. the prevention and elimination of pain during dental treatment has benefited patients, their doctors and dental hygienists, enabling the dental profession to make tremendous therapeutic advances that would otherwise have been impossible. introduced in the late 1940s, the amide local anesthetics represent the most use...