This paper describes a method for fitting 3D object model to still (single) 2D observed image by searching for the model's optimum posture parameters in the parameter space through LMM iteration method (a stabilized Gauss-Newton method). In the method, we propose a new approach to feeding an excellent initial parameter value to the iteration method via aspect identification by applying linear c...

Neoplastic meningitis, also known as carcinomatous meningitis, reflects the metastatic infiltration of the cerebrospinal fluid (CSF) and leptomeninges (pia and arachnoid) by cancer. It is the is the third most common cause of central nervous system (CNS) metastases after brain metastases and epidural spinal cord compression [1]. Leptomeningeal metastasis (LMM) is a devastating complication of m...

Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimate...

OBJECTIVES To assess the margins required for excision of lentigo maligna (LM) and lentigo maligna melanoma (LMM) by the technique of mapped serial excision (MSE), and to assess the efficacy of MSE. DESIGN An interventional, prospective, noncontrolled case series. SETTING Tertiary referral, dermatologic surgery unit. PATIENTS Consecutive patients with head and neck LM or LMM who underwent...

This study aimed to characterize the role of Pseudomonas aeruginosa low-molecular-mass penicillin-binding proteins (LMM PBPs), namely, PBP4 (DacB), PBP5 (DacC), and PBP7 (PbpG), in peptidoglycan composition, β-lactam resistance, and ampC regulation. For this purpose, we constructed all single and multiple mutants of dacB, dacC, pbpG, and ampC from the wild-type P. aeruginosa PAO1 strain. Peptid...

Background: Survivors of cutaneous melanoma (CM) have an increased risk for developing multiple cancers, including melanoma, breast cancer, prostate and non-Hodgkin lymphoma (NHL). Limited data exists comparing differences in second primary cancer (SPC) between CM subtypes. Purpose: To compare the spectrum SPC subtypes (superficial spreading, SSM; lentigo maligna, LMM; acral lentiginous, ALM; n...

In this paper a new class of proximal-like algorithms for solving monotone inclusions of the form T (x) 3 0 is derived. It is obtained by applying linear multi-step methods (LMM) of numerical integration in order to solve the differential inclusion ẋ(t) ∈ −T (x(t)), which can be viewed as a generalization of the steepest decent method for a convex function. It is proved that under suitable cond...

BACKGROUND Lipomyelomeningocele (LMM) is a common and severe closed neural tube defect in children. Because of the complex anatomy of LMM and the difficulty in assessing the value of surgery, the management of patients with LMM is controversial. This study was undertaken to evaluate effective techniques and procedures in surgical treatment of LMM and to assess the value of early neurosurgical i...

We consider the problem of genetic association testing of a binary trait in a sample that contains related individuals, where we adjust for relevant covariates and allow for missing data. We propose CERAMIC, an estimating equation approach that can be viewed as a hybrid of logistic regression and linear mixed-effects model (LMM) approaches. CERAMIC extends the recently proposed CARAT method to ...

BACKGROUND During the Dutch Q fever epidemic more than 4,000 Q fever cases were notified. This provided logistical challenges for the organisation of serological follow-up, which is considered mandatory for early detection of chronic infection. The aim of this study was to investigate the proportion of acute Q fever patients that received serological follow-up, and to identify regional differen...