Introduction: Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by doxorubicin is not clear. The aim of this study was to investigate the pretreatment effect of regular aerobic exercise on hepatic oxidative stress induced with doxorubicin of Wistar rats in differ...

Introduction: Primaquine is one of the essential medicines used to treat malaria due Plasmodium vivax. acts by eradicating hypnozoites in liver, and its effect dependent on drug concentrations target tissue. The present study aimed prepare primaquine nanoparticle formulation using chitosan as carriers improve on-target delivery liver. Methods: Primaquine-loaded nanoparticles were prepared ionic...

background: cadmium (cd) is not considered as essential element for living organisms, therefore its presence in tissues is considered as toxic element. from food hazards control point of view, information on the distribution of these toxic elements in the animal tissues is very important. the present study was designed to evaluate cd distribution pattern in kidney and liver of broiler chicken. ...

introduction in this study, we examined the effects of the antibiotics levofloxacin on the liver as well as its devastating effects which are ensued from its over-prescription. levofloxacin serves as one of the antibiotics of genitourinary system and inferior respiratory system. since liver is the foremost organ that receives all the materials absorbed by intestine through the portal vein, and ...

introduction: one of the minimally invasive methods of treatmenting liver malignancies is radiofrequency ablation (rfa) which can be applied to primary or secondary tumors. nevertheless, the disease recurrence is probable after rfa application partially due to the inadequate capability of temperature monitoring of the target tissue and visualizing the thermal damage. the goal of this work was t...

Cartilaginous fish species have ecological importance. Besides, the ecotoxicological studies on these are pretty insufficient. In this study, Al, Cr, Mn, Fe, Cu, Zn, As, Pb, Cd, and Sr levels were determined in muscle, liver, gill, kidney, spleen, stomach, gonad tissues of Alopias superciliosus (Female, 240 cm TL) caught from Mersin Bay. Tissue metal analysis was by Inductively Coupled Plasma M...

Introduction: Lead is one of the most important environmental pollutants due to its vast use in various industries. Lead accumulation in different organs, especially the brain, liver and kidneys can cause serious health problems. Lead exposure is more dangerous during fetal period and childhood. Materials and Methods: Timed pregnant female rats divided into 6 groups. Group 1served as control g...

Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r, Insr, and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glarg...