there is still been no report of splenic involvement in the wake of colon cancer. in this case, air was seen in the spleen and liver following the penetration of colon cancer to the continuous spleen. colon cancers always do not present with clear and common symptoms. some times with a non-specific and uncommon symptoms and signs present that would be amazed physicians and researchers. it is ve...

Deregulation of the epigenome component affects multiple pathways in the cancer phenotype since the epigenome acts at the pinnacle of the hierarchy of gene expression. Pioneering work over the past decades has highlighted that targeting enzymes or proteins involved in the epigenetic regulation is a valuable approach to cancer therapy. Very recent results demonstrated that inhibiting the epigene...

Background: Hepatocellular carcinoma (HCC), primary liver cancer, is a major health problem and the third most common cause of cancer-related deaths worldwide. Epigenetic modulations are essential for the maintenance of gene expression patterns in mammals. Disruption of these processes can lead to silenced gene and malignant cellular transformation. The current study was designed to compare the...

Therapies for liver cancer particularly those including radiation are still inadequate. Inhibiting the stress response machinery is an appealing anti-cancer and radiosensitizing therapeutic strategy. Heat-shock-protein-90 (HSP90) is a molecular chaperone that is a prominent effector of the stress response machinery and is overexpressed in liver cancer cells. HSP90 client proteins include critic...

Abstract Objectives The inhibitory mechanism of growth differentiation factor 11 (GDF11) on liver cancer cells is unknown. Our study applied RNA-Seq to investigate the transcriptome results after GDF11 treatment, revealing underlying molecule mechanisms roles cells. Methods First, mRNA and protein expression levels were detected through Oncomine database tissue microassay. In vitro , Smad2/3 si...

The effects of tocotrienols on murine liver cell viability and their apoptotic events were studied over a dose range of 0-32 microg mL(-1). Normal murine liver cells (BNL CL.2) and murine liver cancer cells (BNL 1ME A.7R.1) were treated with tocotrienols (T(3)), alpha tocopherol (alpha-T) and the chemo drug, Doxorubicin (Doxo, as a positive control). Cell viability assay showed that T(3) signif...

Liver cancer remains one of the most lethal malignancies worldwide. We sequenced the complete mitochondrial genome of a liver cancer HA22T cell line. The sequenced mitogenome of 16,603 bp will aid in the use of the HA22T cell line for liver cancer study.

background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...

objective(s): development of molecules that specifically recognize cancer cells is one of the major areas in cancer research. human epidermal growth factor receptor 2 (her2) is specifically expressed on the surface of breast cancer cells. her2 is associated with an aggressive phenotype and poor prognosis. in this study we aimed to isolate rna aptamers that specifically bind to her2 overexpressi...