N on-alcoholic fatty liver disease (NAFLD) is a clinicopathological condition characterised by a wide spectrum of histological abnormalities and clinical outcomes. The underlying histological abnormality is hepatic steatosis, characterised by fat accumulation, which may progress to non-alcoholic steatohepatitis (NASH), characterised in turn by steatosis, periportal inflammation, and ballooning ...

Hepatomegaly is a common finding in primary myelofibrosis (PMF), mostly due to extramedullary hematopoiesis, as demonstrated by liver biopsies in previous studies, and high serum alkaline phosphatase (ALP) is usually the most frequent associated biochemical abnormality. In the current study, we examined the clinical, prognostic and molecular correlates of increased ALP and aspartate aminotransf...

Portal vein thrombosis is an unusual potential complication of liver resection. In our case it was due to ligation of the right branch of the portal vein during right hepatectomy in a patient without portal vein bifurcation. Hepatic angiography can delineate this abnormality and influence the choice of surgical management.

background: different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats. objective: in this study we worked out the effect of methoxsalen together with ultraviolent a (uva) radiation on mature balb/c mice spermatogenesis. materials and methods: the ld50 standard was determined 160 mg/kg and the uva dose which causes erythema was calculated 0.046 j...

Catalase (E.C. 1.11.1.6) activity and NADPH-dependent lipid peroxidation have been measured in liver microsomes from normal and acatalasemic mice. The absence of lipid peroxidation in acatalatic microsomes is not restituted by exogenous catalase as is microsomal methanol oxidation nor is it inhibited by sodium azide, thus suggesting an additional abnormality in these mice.

Liver disease during chemotherapy and after its completion was studied in 103 leukemic children in long-term remission. Seventy developed chronic liver disease during therapy; 22 out of 56 with adequate follow-up showed persisting abnormality or deterioration of liver function after stopping therapy. In 38 studied prospectively, biopsies were obtained at treatment withdrawal. Five showed chroni...