Chronic heart failure (CHF) is associated with endothelial dysfunction. Activation of the renin-angiotensin-aldosterone system (RAAS) is believed to be important in the deterioration of endothelial dysfunction in CHF through stimulation of oxidative stress. Whereas angiotensin-converting enzyme inhibitors (ACE-I) improve endothelial function in CHF, the effects of angiotensin II AT1-receptor bl...

Systemic inhibition of the renin-angiotensin-aldosterone system (RAAS) has been recently suggested to participate in the regulation of seizures susceptibility. The purpose of the current study was to evaluate the effect of lisinopril and valsartan as RAAS modifiers on the protective action of the antiepileptic sodium valproate (VPA) against pilocarpine-induced convulsions in mice. Male albino m...

Several studies have suggested that angiotensin converting enzyme inhibitors retard the process of cataractogenesis by scavenging free oxygen radicals. The present study sought to assess the efficacy of the ACE inhibitor Lisinopril in preventing selenite-induced cataractogenesis in an experimental setting. The in vitro phase of the study was performed on lenses from wistar rats incubated for 24...

To investigate lisinopril effect on the contribution of nitric oxide (NO) and K(Ca) channels to acetylcholine (ACh)-induced relaxation in isolated mesenteric arteries of spontaneously hypertensive rats (SHRs). Third branch mesenteric arteries isolated from lisinopril treated SHR rats (20 mg/kg/day for ten weeks, SHR-T) or untreated (SHR-UT) or normotensive WKY rats were mounted on tension myogr...

OBJECTIVE To assess 1-year persistence and adherence with monotherapy using the most commonly dispensed individual agent in 4 antihypertensive drug classes: hydrochlorothiazide (HCTZ), amlodipine, lisinopril, or valsartan. DESIGN Retrospective, longitudinal analysis of initial prescriptions during 2001 to 2002 from a nationwide administrative claims database representing 11 million covered li...

The aim of this trial was to examine the effects of antihypertensive fixed combination of lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd, Bosnia and Herzegovina) on regression of left ventricular hypertrophy in patients with essential arterial hypertension. We included 297 patients in our trial, aged 54.65+/-9.6 years, with treated or untreated hypertension and with high risk of c...

Angiotensin-converting enzyme (ACE) inhibitors represent the front-line pharmacological treatment of heart failure, which is characterized by left ventricular (LV) dilatation and inappropriate hypertrophy. The mechanism of action of ACE inhibitors is still unclear, but evidence suggests that they may act by influencing matrix metalloproteinase (MMP) activity. This study sought to determine whet...

Angiotensin-converting enzyme inhibitors restore size-selective dysfunction of the glomerular barrier in experimental animals and humans with proteinuric nephropathies, although the structural and molecular determinants of such an effect are not completely understood. This study used an accelerated model of experimental nephrosis to assess nephrin gene and protein expression in the kidney and t...

Alcohol abuse increases the incidence of acute respiratory distress syndrome and causes oxidative stress and cellular dysfunction in the lung. The mechanisms of ethanol (EtOH)-induced oxidative stress in the lung remain to be defined. Chronic alcohol ingestion has been associated with increased renin-angiotensin system (RAS) activity. Therefore, the current study investigated the ability of lis...

Department of Pharmacology, Objectives: To study, the anticataract activity of lisinopril and enalapril on cataract inGrant Medical College, duced by glucose, in goat lenses. Mumbai, Materials and Methods: Goat lenses were incubated in artificial aqueous humor contain­ *Ranbaxy Laboratories Ltd., **Department of Biochemistry, ing 55 mM glucose (cataractogenesis) with lisinopril or enalapril in ...