INTRODUCTION Although rare, angioedema has been documented to occur following the administration of angiotensin-Converting Enzyme Inhibitors. Angiotensin-converting enzyme inhibitors are the leading cause of drug induced angioedema. Angiotensin-converting enzyme inhibitors induced angioedema is a class effect that can affect between 0.1% and 0.5% of patients taking the drug. It is rarely docume...

Lisinopril is used to treat hypertension, congestive heart failure and to improve survival after a heart attack. Learn about side effects, interactions and indications. PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their. Identify these contraindicated and dangerous lisinopril oral (P...

Medications are often overlooked as a potential cause of acute pancreatitis. In many cases we rely on postmarketing surveillance of new medications to characterize their adverse effect profile, which might include acute pancreatitis. Whereas estrogen-induced pancreatitis is relatively well-recognized, the association of pancreatitis with the newer agents such as angiotensin-converting enzyme (A...

BACKGROUND Reference-based pricing is a cost-containment policy applied to prescription drugs that are in the same class and deemed to be therapeutically equivalent. Recent reference-based pricing measures have targeted several drug classes, including angiotensin-converting-enzyme (ACE) inhibitors. The objective of this study was to assess whether patients treated for hypertension with various ...

BACKGROUND Treatments that reduce inflammation and cardiovascular disease (CVD) risk among individuals with HIV infection receiving effective antiretroviral therapy (ART) are needed. DESIGN AND METHODS We conducted a 2 × 2 factorial feasibility study of lisinopril (L) (10 mg daily) vs L-placebo in combination with pravastatin (P) (20 mg daily) vs P-placebo among participants receiving ART wit...

The peptide angiotensin-converting enzyme inhibitors captopril and lisinopril are unexpectedly shown to exhibit critical aggregation concentration (CAC) behavior through measurements of surface tension, electrical conductivity, dye probe fluorescence. These three provide similar values for the CAC, there is also evidence from circular dichroism spectroscopy a possible conformational change in p...

In the VALUE trial, new-onset diabetes arose in significantly fewer hypertensive patients on valsartan, an angiotensin receptor AT1 blocker (ARB), than on amlodipine, a metabolically neutral calcium-channel blocker, after a mean follow-up of 4.2 years. This finding confirms and extends the results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) in whi...

A high performance liquid chromatographic method was developed, validated and applied for determination of lisinopril in pharmaceutical formulations. A LiChrospher RP-18 (10 μm, 250x 4 mm) column was used with a mobile phase consisting of acetonitrile: phosphate buffer (30: 70% v/v, pH 2.0), a quantitative evaluation was performed at 215 nm with flow rate of 1 mL/min, and column cooler temperat...