نتایج جستجو برای: liquid phase separation

تعداد نتایج: 874838  

The present study was designed to develop a simple, validated liquid chromatographic method for the analysis of azithromycin in bulk and pharmaceutical dosage forms using ultraviolet detector. The best stationary phase was determined as C18 column, 5 µm, 250 mm × 4.6 mm. Mobile phase was optimized to obtain a fast and selective separation of the drug. Flow rate was 1.5 mL/min, Wavelength was se...

2018
Susanne Wegmann Bahareh Eftekharzadeh Katharina Tepper Katarzyna M Zoltowska Rachel E Bennett Simon Dujardin Pawel R Laskowski Danny MacKenzie Tarun Kamath Caitlin Commins Charles Vanderburg Allyson D Roe Zhanyun Fan Amandine M Molliex Amayra Hernandez-Vega Daniel Muller Anthony A Hyman Eckhard Mandelkow J Paul Taylor Bradley T Hyman

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation. We demonstrate that phosphoryla...

2017
Louis-Philippe Bergeron-Sandoval Hossein Khadivi Heris Adam G. Hendricks Paul François Rohit V. Pappu Stephen W. Michnick

Département de Biochimie, Université de Montréal, C.P. 6128, Succursale centre-ville, 9 Montréal, Québec, H3C 3J7, Canada. 10 Department of Bioengineering, McGill University, Montreal, Quebec, H3A0C3, Canada. 11 Ernest Rutherford Physics Building, 3600 rue University, McGill University, Montreal, Québec, 12 H3A2T8 13 Department of Biomedical Engineering and Center for Biological Systems Enginee...

2003
P. van de Witte

This review covers new experimental and theoretical physical research related to the formation of polymeric membranes by phase separation of a polymer solution, and to the morphology of these membranes. Two main phase separation processes for polymeric membrane formation are discussed: thermally induced phase separation and immersion precipitation. Special attention is paid to phase transitions...

Journal: :Chemical communications 2015
David L Minnick Aaron M Scurto

A novel physical (non-reactive) separation of cellulose from an ionic liquid (IL)/cosolvent mixture by compressed carbon dioxide is presented. The precipitation is completely reversible and rapid within small changes of pressure i.e. liquid phase CO2 composition. High pressure phase equilibrium, high pressure NMR, and solid state NMR have been utilized to understand the separation phenomena.

Journal: :The journal of physical chemistry. B 2006
Sylvain Grouazel Françoise Bonneté Jean-Pierre Astier Natalie Ferté Javier Perez Stéphane Veesler

This paper presents an investigation of the phase diagram of BPTI (bovine pancreatic trypsin inhibitor)/350 mM KSCN at pH 4.9 by direct observation and numerical simulations. We report optical microscopy and light and X-ray scattering experiments coupled with theoretical data analysis using numerical tools. The phase diagram is thoroughly determined, as a function of temperature. Two polymorphs...

2017
Gerda C. M. Vreeker Manfred Wuhrer

Reversed-phase chromatography is a method that is often used for glycan separation. For this, glycans are often derivatized with a hydrophobic tag to achieve retention on hydrophobic stationary phases. The separation and elution order of glycans in reversed-phase chromatography is highly dependent on the hydrophobicity of the tag and the contribution of the glycan itself to the retention. The c...

Reverse micellar systems are nanofluids with unique properties that make them attractive in high selectivity separation processes, especially for biological compounds. Understanding the phase behavior and thermodynamic properties of these nanosystems is the first step in process design. Separation of components by these nanosystems is performed upon contact of aqueous and reverse micellar phase...

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