This study proposed a decomposed SCORM (Sharable Course Object Reference Model) structure with embedded LCMS Broker that provides the integration of learning resources and balance of network traffic. The system consists of the Learning Management System (LMS) for processing basic data, learning data and learning records of learners, and the Learning Content Management Systems (LCMSs) for managi...

Tripterygium wilfordii (Hook. f.) is a woody vine of the Celastraceae family, and native to China (south of the Yangtze River), Korea, and Japan, is used in the clinic for the treatment of inflammatory and autoimmune diseases, especially rheumatoid arthritis. In this study, we developed a urine metabolomic method by gas chromatographymass spectrometry (GC-MS) to evaluate the effect of Tripteryg...

194 CLINICAL CHEMISTRY, Vol. 25, No. 1, 1979 gas chromatography before and after acid (6 mol/L HC1) and alkaline (NaOH) hydrolysis. We frequently observe a peak in the lactic acid position after alkaline hydrolysis. After acid hydrolysis of the same urine no lactate isobserved, but a peak appears in the position of levulinic acid. The mass spectra of these two peaks were identical with those of...

During barrel maturation, the volatile compounds extracted from oak wood can contribute to a wine’s overall aroma and flavour, enhancing its character and complexity. However, barrels have a finite pool of extractable material and the amounts of oak derived volatile compounds available for extraction diminish over time. As a consequence, barrels are typically decommissioned after five to six ye...

dispersive liquid-liquid microextraction technique based on solidification of a floating organic drop (dllme-sfo) combined with flame atomic absorption spectrometry was developed for determination of thallium in water sample. an appropriate mixture of acetone and 1-undecanol was rapidly injected into an aqueous sample containing tlcl4- which forms an ion pair with brilliant green reagent and as...

The cytochrome P450-mediated Phase I in vitro metabolism of CRV431 was studied using selective chemical inhibition and recombinant human enzymes. Additionally, the metabolic profile of CRV431 in human, rat, and monkey liver microsomes was investigated. Liver microsomes were incubated for 0-80 min with CRV431, and the metabolite profile was assessed by electrospray ionization liquid chromatograp...

BACKGROUND/OBJECTIVES One of the mechanisms considered to be prevalent in the development of Alzheimer's disease (AD) is hyper-stimulation of microglia. Black chokeberry (Aronia melanocapa L.) is widely used to treat diabetes and atherosclerosis, and is known to exert anti-oxidant and anti-inflammatory effects; however, its neuroprotective effects have not been elucidated thus far. MATERIALS/...

Dicathais orbita is a large Australian marine gastropod known to produce bioactive compounds with anticancer properties. In this research, we used bioassay guided fractionation from the egg mass extract of D. orbita using flash column chromatography and identified fractions containing tyrindoleninone and 6-bromoisatin as the most active against colon cancer cells HT29 and Caco-2. Liquid chromat...

the lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. the present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. a liquid chromatography–electrospray ionization–mass spectrometry (lc–esi–ms) method for the qualitative and quantitative determination of the metabolites...