Polycyclic aromatic hydrocarbons (PAH) are ubiquitous persistent organic pollutants forming as byproducts in combustion processes. These compounds can become nitrated the environment even more toxic nitro derivatives. Both PAHs and nitro-PAHs accumulate soils which lead to pollution of vast areas arable land. The best means their elimination from is bioremediation that degradation by soil micro...

Lipid peroxidation is common to all biological systems, appearing in developmentally-regulated processes and as a response to environmental changes. Products derived from lipid peroxidation are collectively named oxylipins. Initial lipid peroxidation may either occur by enzymatic or chemical reactions. An array of alternative reactions further converting lipid hydroperoxides gives rise to a lar...

The antioxidant and radical scavenging properties of 8-oxo derivatives of pentoxifylline, lisofylline, enprofylline (3-propyl xanthine), and 1,7-dimethyl enprofylline were studied in vitro. The results show that 8-oxopentoxifylline and 8-oxolisofylline are significantly better hydroxyl and peroxyl radical scavengers and more potent inhibitors of t-butylhydroperoxide-induced lipid peroxidation i...

G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets. New technologies have been developed for the identification of new ligands, new GPCR functions, and for drug discovery purposes. In particular, intercellular lipid mediato...

Article history: Received on: 13/06/2016 Revised on: 17/07/2016 Accepted on: 18/09/2016 Available online: 31/01/2017 Multiple factors, such as increased intestinal barrier permeability, upregulation of iNOS/NO expression and decreased H2S synthesis are involved in the pathogenesis of inflammation. The purpose of this investigation was to explore the role of 4-thiazolidinone-based derivatives as...

Two spin-labelled derivatives of the 5-(2-indolyl)-2,4-pentadienoyl class of inhibitors of the vacuolar ATPase have been synthesised and their EPR properties characterised in phospholipid membranes. One spin-labelled inhibitor is the amide derivative of pentadienic acid and 4-amino-TEMPO (INDOL6), and the other is the 3-hydroxymethyl-PROXYL ester (INDOL5). The response of the EPR spectra to the...

The peptidoglycan of bacterial cell walls is biosynthesized in a complex reaction cycle in which lipid intermediates serve as carriers of activated sugar fragments (1). The lipid intermediates (e.g., lipid-P-P-disaccharide-pentapeptide) have been identified as derivatives of an acyclic isoprenoid alcohol which has a chain length of 11 isoprene units (2, 3). In the cyclic reaction, the disacchar...