the water content of the epidermis is a main factor in maintaining skin smoothness and elasticity and preventing skin dryness. occlusive products can greatly affect skin hydration by forming a barrier on the skin following the topical administration of oil-based formulations. these products repair the skin barrier by restoring the skin lipids as well. solid lipid nanoparticles (slns) have recen...

The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulati...

Berberine is an isoquinoline alkaloid possesses multitude of biological effects. However, quaternary amine cation berberine causes poor water solubility, resulting in low bioavailability which limits its pharmacological purpose. The aim this study was to prepare and optimize loaded solid lipid nanoparticle evaluate pharmacokinetic antihyperlipidemic activity. nanoparticles were prepared by solv...

The present study is aimed to investigating the formulation and in vitro anticancer activities of solid lipid nanoparticles of 5 Fluorouracil (5-FU) prepared using glyceryl monostearate (GMS) and cetyl palmitate (CP) through hot homogenization method. The lipids were selected based on the partition coefficient of 5-FU in lipids. The lipid nanoparticles were optimized for process and formulation...

Lipid based formulations (LBFs) can enhance oral bioavailability, however, their utility may be restricted by low drug loading in the formulation. Converting drugs to drug-ionic liquids (drug-ILs) or lipophilic salts significantly increase lipid solubility but this approach is complicated some cases salt disproportionation, leading a reduction and physical instability. Here we explore stability...

cyproterone acetate (ca) has been loaded to liposome by solvent evaporation and thin film formation technique. the effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. the data showed that bigger balloon with higher surface area has b...