background chromosomal aberrations are one of the most common causes of mental retardation (mr). objectives in this study, in order to identify the rate of chromosomal abnormalities in idiopathic mr, 50 mr patients at a charity center in hamadan, iran, were investigated. methods fifty mentally retarded male patients without specific chromosomal abnormalities (e.g., down syndrome, fragile x synd...

background: the prevalence of intestinal parasites infection in institutions for mental retarda­tion of ur­mia city, west azerbaijan province, iran was investigated. methods: this descriptive - cross sectional study was carried out in of urmia city in 2007-2008. fecal samples of 225 less than 29 year old mentally disabled individu­als were examined using direct smear, formalin - ether concen­tr...

INTRODUCTION We identified a female patient with mental retardation and sensory hyperarousal. She has a de novo paracentric inversion of one X chromosome with completely skewed inactivation of the normal X chromosome. OBJECTIVE We aimed to identify whether a single gene or gene region caused her cognitive and behavioural impairment and that of others. RESULTS Fluorescent in situ hybridisati...

I N 1955 three mice with very small eyes were observed in a stock segregating for the gene Patch. These animals all came from the same mating and on investigation proved to be homozygous for a new gene causing a reduction in the blood-supply of the eyes at a critical embryonic stage. The original animals where also Ph[-\-, but this gene was soon eliminated from the new stock and had nothing to ...

The neuronal cell adhesion molecule L1 (L1CAM) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and is essential in the development of the nervous system. It is mainly expressed on neurons and Schwann cells, and plays a key role in axon outgrowth and pathfinding through interactions with various extracellular ligands and intracellular second messenger systems. Mutatio...

Mental retardation represents a deficiency in intelligence, as measured by IQ, with limited adaptive behavior that is normally reflected in maturation, learn­ ing, or social adjustment (American Psychiatric Association 1987). Approxi­ mately 1 to 3% of the population, depending upon definitions of adaptive behavior, is mentally retarded (Popper 1988). The etiologies and determinants of mental r...

mental retardation (mr) is one of the most frequently found major genetic disorders around the world, affecting 1-3% of the people in the general population. the recent advancement in molecular biology and cytogenetic study has made possible the identification of new genes for a variety of genetic disorders including autosomal recessive mr. recessive genetic disorders are common in pakistan due...

how to cite this article: gajewska e, sobieska m, samborski w. associations between manual abilities, gross motor function, epilepsy, and mental capacity in children with cerebral palsy. iran j child neurol. 2014 spring 8(2):45-52. objective this study aimed to evaluate gross motor function and hand function in children with cerebral palsy to explore their association with epilepsy and mental c...

fryns-aftimos syndrome is a rare autosomal dominant disorder characterized by craniofacial signs, anterior neuronal migration disorder (pachygyria, lissencephaly), skeletal deformities and mental retardation. we describe a five-year-old boy with abnormal facial features (hypertelorism, ptosis, high arched palate), skeletal problems (short stature, short fingers, flat feet) and mild intellectual...

Mental retardation is the most frequent cause of serious handicap in children and young adults. The underlying causes of this heterogeneous condition are both acquired and genetically based. A recently performed refinement of the linkage interval in a large Belgian family with mild to severe non-syndromic X linked mental retardation, classified as MRX9, revealed a candidate region of 11.3 Mb be...