aim : in this study, genetic polymorphism of two trna-liked short tandem repeat (str)-containing loci, r-r and s-q, was analyzed in order to clarify further the genotypic differences among e. dispar isolates. background : entamoeba dispar is closely related to the human pathogen e. histolytica , the agent of amebic dysentery and amebic liver abscesses. e. dispar is, to some extent, capable of p...

Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease that affects 2%–3% of the world's population. It related to genetic vulnerability, autoimmunity, mental health, and environmental factors. Pathogenesis highly linked abnormal interactions between innate immunity, T lymphocytes, keratinocytes. Maresin 1 (Mar1) one EPA-derived metabolites with substantial anti-inflammatory ac...

X-linked parkinsonism encompasses rare heterogeneous disorders mainly inherited as a recessive trait, therefore being more prevalent in males. Recent developments have revealed complex underlying panorama, including spectrum of which is variably associated with additional neurological and non-neurological signs. In particular, childhood-onset encephalopathy epilepsy and/or cognitive disability ...

Congenital cataract is a common cause of blindness in children; however, its pathogenesis remains unclear. Genetic factors have been shown to play an important role in the pathogenesis of congenital cataract. The current genetic models of congenital cataract include autosomal dominant, autosomal recessive, and sex-linked inheritance. Sex-linked congenital cataract could be inherited through the...

BACKGROUND Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology that causes arrhythmias, heart failure, and sudden death. Diagnosis can be difficult, and this hampers investigation of its molecular basis. Forms of ARVC in which gene penetrance and disease expression are greater should facilitate genetic study. We undertook a clinical and genetic i...

puccinia recondite (leaf rust) is an endemic disease in iran; this disease can affect the productivity and quality of wheat, that occurring in all wheat growing regions. genetic resistance to leaf rust of wheat is the most important strategy to control the diseases and 51 leaf rust resistance genes (lr gene) are reported in wheat to provide resistance to leaf rust. this study aims to identify p...

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...

Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...