Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the antimicrobial and immunological properties and the feasibility of using NPs to deliver antimicrobial agents to treat a cutaneous pathogen. NPs synthesized with chitosan and alginate demonstrated a direct antimicrobial activity in vitro agai...

Bacterial colonization and subsequent biofilm formation is still one of the major problems associated with medical devices. Antimicrobial peptides (AMP) immobilization onto biomaterials surface is a promising strategy to avoid bacterial colonization. However, a correct peptide orientation and exposure from the surface is essential to maintain AMP antimicrobial activity. This work aims to evalua...

Chitosan microspheres of a small particle size and with good sphericity were prepared by a spraydrying method followed by treatment with a cross-linking agent. Owing to restrictions on the use of crosslinked chitosan microspheres in the pharmaceutical field, d,l-glyceraldehyde, a biocompatible reatant was used. The parameters studied affecting extent of cross-linking were cross-linking time and...

Chitosan is a natural polymer composed of randomly distributed -(1-4)-linked D-glucosamine (deacetylated unit) and Nacetyl-D-glucosamine (acetylated unit). It has been described as a non-toxic, biodegradable and biocompatible polymer with very interesting biological properties, such as permeation-enhancing and mucoadhesive properties, anticoagulant and antimicrobial activity and so on. Chitosan...

A chelating resin, cross-linked chitosan modified with the glycine moiety (glycine-type chitosan resin), was developed for the collection and concentration of bismuth in aquatic samples for ICP-MS measurements. The adsorption behavior of bismuth and 55 elements on glycine-type chitosan resin was systematically examined by passing a sample solution containing 56 elements through a mini-column pa...

A composite scaffold was successfully fabricated using β-tricalcium phosphate (βTCP), which is extracted from limestone by first sintering and then reacting it with phosphoric acid through wet precipitation method. The resultant substance mixed chitosan gelatin. This novel method utilizes limestone, abundant in nature. study optimizes the fabrication βTCP evaluating effect of glutaraldehyde on ...

This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to monitor the dynamic viscoelastic parameters during in situ (i.e., in the rheom...

Laccase from Coriolopsis Polyzona was insolubilized as cross-linked enzyme aggregates (CLEAs) for the first time with chitosan as the cross-linking agent. Concentrations between 0.01 and 1.867 g/L of chitosan were used and between 0.05 and 600 mM of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride. The laccase was precipitated using ammonium sulphate and cross-linked simultaneously. ...

Abstract Removal of heavy metals and dyes from wastewater has received great attention due to scarcity clean water worldwide. Herein an approach was introduced attain this goal by employing a single material. Chitosan films were prepared, cross-linked it utilized for the adsorption cobalt aqueous medium. The adsorbed chitosan then reutilized as photocatalyst photodegradation methyl violet dyes....

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in field pain therapy. Thanks to bonding chitosan mucosa and its permeability-enhancing effect, it is excellent choice formulate microspheres for increase drug bioavailability. aim our work includes preparation spray-dried cross-linked non-cross-linked chitosan-based de...