نتایج جستجو برای: link damage
تعداد نتایج: 412435 فیلتر نتایج به سال:
The BAL1 macrodomain-containing protein and its partner E3 ligase, BBAP, are overexpressed in chemotherapy-resistant lymphomas. BBAP selectively ubiquitylates histone H4 and indirectly promotes early 53BP1 recruitment to DNA damage sites. However, neither BBAP nor BAL1 has been directly associated with a DNA damage response (DDR), and the function of BAL1 remains undefined. Herein, we describe ...
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitochondrial DNA (mtDNA) damage can compromise mitochondrial function, we examined whether LRRK2 mutations can induce damage to the mitochondrial genome...
In this paper a micromechanical approach to damage growth in graphrepresentable microstructures is presented. Damage is denned as an elasticinelastic transition in the grain boundaries and is represented in terms of a binary or ternary random field Z on the graph. A method based on the percolation theory brings out the size effects in scatter of strength, and the fractal character of damage geo...
Fully packaged InGaAs p-i-n photodiodes for use in CMS Tracker optical digital timing and control links have been irradiated at room temperature with 330MeV positive pions. Measurements of the leakage current and photocurrent response were made in-situ for pion fluences up to 3.9x10π/cm. The leakage current increases from <1nA to 40μA at 5V reverse bias and the photocurrent for 100μW incident o...
The laser damage resistance of optical coatings is a key point for a large number of applications. The aim of this work is to test and analyze the laser damage resistance of a thin film material commonly used for high power applications (SiO2) and deposited with different techniques: Electron Beam Deposition, Ion Assisted Deposition, Low Voltage Reactive Ion Plating and Dual Ion Beam Sputtering...
from the time that civil engineers have used steel in building structures, they tried to increase its strength so as to produce more economic and lighter structures by using more elegant sections. increase of steel strength is not always useful for all members of a steel structure. in some members under certain conditions, it is needed to reduce the strength as much as possible to improve the b...
in this paper, a crack localization method for euler-bernoulli beams via an efficient static data based indicator is proposed. the crack in beams is simulated here using a triangular variation in the stiffness. static responses of a beam are obtained by the finite element modeling. in order to reduce the computational cost of damage detection method, the beam deflection is fitted through a poly...
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