نتایج جستجو برای: linezolid prescription
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4 Theoretically estimated AUC 24 /MIC ratios against VRE susceptible to linezolid, according to the EUCAST clinical breakpoint (MIC¼ 4 mg/L), 1 were in the recommended range for the effective treatment of severe infections with linezolid (AUC 24 /MIC ratio of 80 –120) 6 in both cases (.93.76 and .250.96, respectively). In addition , biliary trough levels (C min) of linezolid were above the EUCA...
Sir, Previous studies in a rabbit model of staphylococcal endo-carditis have demonstrated significant antibacterial effects with the oxazolidinone linezolid. 1,2 In those studies, increases in peak and trough linezolid plasma levels were noted between the first and final doses of the 5 day treatment period. We report results of additional studies to determine the effects of treatment duration o...
Sir, We read with great interest the article ‘Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients’ by Koh et al., in which they describe retrospectively examined records of one of the largest case series of patients treated with linezolid for multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-T...
OBJECTIVES To determine the concentration-time curves of linezolid in serum and vitreous from 24 patients undergoing vitrectomy. METHODS Vitrectomy was performed 1, 2, 4, 8 and 12 h after infusion of 600 mg of linezolid in 20 patients divided into groups of four. Four additional patients were studied 12 h after two separate oral doses of 600 mg of linezolid. Serum samples were obtained 1 h af...
The emerging resistance to antibiotics and the poor pipeline of new antibacterials is creating a major health issue worldwide. Combinations of two antibiotics or antibiotics with adjuvant are emerging as a promising therapeutic approach. Staphylococcus aureus represents a major threat to a broad range of healthcare and community associated infections. It is imperative to develop novel antimicro...
Abstract Background and Objective: Vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) are the leading nosocomial pathogens in Iran. We aimed at evaluating the resistance patterns of Staphylococcus aureus and enterococci to the antibiotics recommended by Clinical and Laboratory Standards Institute (CLSI). Material and Methods: Two-hu...
Staphylococcus species are one of the major causes of bacterial bloodstream infections. Multi-resistant staphylococci infections are major therapeutic problems. This study was aimed to detect methicillin, linezolid and vancomycin susceptibilities of Staphylococcus isolates. A total of 870 Staphylococcus strains isolated from blood cultures of hospitalized patients with BSI. Antimicrobial suscep...
BACKGROUND The common adverse effects of linezolid for treating septic patients with gram-positive cocci is anemia and thrombocytopenia, which limit its clinical application. OBJECTIVES We determined the effects of vitamin B6 adjunctive therapy on linezolid-associated cytopenias, and retrospectively studied 75 septic patients who received at least 7 days of linezolid treatment. METHODS Pati...
The nasopharynx plays a critical role as the reservoir of Streptococcus pneumoniae, including drug-resistant strains particularly in children attending day care centers. A total 58 nasopharyngeal, multiresistant isolates of S. pneumoniae collected from healthy pre-school children were susceptible to linezolid (MIC = 0.25-1 mg/l), irrespective of serotype and drug resistance pattern. The majorit...
The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 microg/m...
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