نتایج جستجو برای: limited constraint method lcm
تعداد نتایج: 2047706 فیلتر نتایج به سال:
Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case represents the first instance of LCM-induced atrial fibrillation following a low loading dose (20...
We present a general framework for Bayesian case-based reasoning and prototype classification and clustering — Latent Case Model (LCM). LCM learns the most representative prototype observations of a dataset by performing joint inference on cluster prototypes and features. Simultaneously, LCM pursues sparsity by learning subspaces, the sets of few features that play important roles in characteri...
Incidence and mortality rates of anal cancer are increasing globally. More than 90% of anal squamous cell carcinomas (ASCC) are associated with human papillomavirus (HPV). Studies on HPV-related anogenital lesions have shown that patterns of methylation of viral and cellular DNA targets could potentially be developed as disease biomarkers. Lesion-specific DNA isolated from formalin-fixed paraff...
PURPOSE This non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide (LCM-iv) under routine conditions in daily clinical practice as a prospective registry. METHODS Patients with any type of seizure or epilepsy syndrome were recruited in 16 neurological and neuropediatric centers in Germany if the treating physician decided to administer LCM-...
The response of human myeloid leukemia cells to various sources of colony-stimulating activity (CSA) and media conditioned by phytohemagglutinin-stimulated mononuclear cells (PHA-LCM) was investigated in liquid and colony culture. PHA-LCM, placenta-conditioned medium, GCT cell line-conditioned medium, leukocyte-conditioned medium, and partially purified CSA for human and murine cells were teste...
To investigate the relatedness of soluble and pelletable vesicular erythroid burst-promoting activity (BPA) present in lymphocyte-conditioned medium (LCM), we immunized rabbits with partially purified lymphocyte plasma membranes and tested the antisera for biological and immunologic crossreactivity with LCM and its component fractions. When preincubated with IgG purified from post-immune but no...
Lacosamide (LCM) is a newer antiepileptic drug with a dual mode of action. It selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, and modulates collapsing response mediator protein 2 (CRMP-2). It has a high oral bioavailability of approximately 100%. It has shown potent and broad neuroprotective effects in vitro and in vivo animal models ...
The anterior pituitary gland consists of a heterogeneous population of various cell types. To study a single cell type with a homogeneous cell population, one can perform laser capture microdissection (LCM). Because different pituitary cells have unique immunophenotypic profiles, it is possible to perform immunohistochemical staining before LCM (immuno-LCM) for the collection of a phenotypicall...
We study the sequences generated by neuronal recurrence equations of the form x(n) = 1[ ∑k j=1 ajx(n − j) − θ], where k is the size of memory (k represents the number of previous states x(n − 1), x(n − 2), . . . , x(n − k) which intervene in the calculation of x(n)). We are interested in the number of steps (transient length) from an initial configuration to the cycle. We propose a method of co...
مدل عصبی-فازی خطی محلی یک سیستم فازی با ساختار شبکه های عصبی مصنوعی است که ساختار قوانین فازی (مدلهای محلی) آن همانند قوانین فازی در مدلهای فازی تاکاگی-سوگنو-کانگ (tsk) بوده و از امتیاز محلی گرایی برای تقریب و شناسایی بهره می برد. درخت مدل خطی محلی یا lolimot الگوریتمی بر پایه استراتژی تقسیم و حل برای ساخت مدلهای عصبی-فازی خطی محلی می باشد. در این الگوریتم حل مسأله پیچیده با کمک تقسیم مسأله اصل...
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