The perception of pain is highly complex, and requires neural integration from a variety of routes. Spinal pathways to the amygdala, hypothalamus, reticular formation, medial thalamic nuclei, and limbic cortical structures transmit information involved arousal, bodily regulation, and emotional responses. Other, albeit indirect, pathways can carry signals to these same structures, for example, f...

Abstract Paraneoplastic neurological syndromes have only been described with pleural mesothelioma in five cases. We have described a 72-year-old man who developed anterograde amnesia 27 months after diagnosis of epithelioid pleural mesothelioma. Investigations revealed a limbic encephalitis with no alternative causes identified. Limbic encephalitis is a classical paraneoplastic syndrome and pre...

The control of the limbic system of brain over visceral and metabolic activities in the body has attracted the attention of many workers in the past few years (Anand, 1957). Various visceral and metabolic effects ofstimulations of different limbic structures have already been reported (Kaada, 1951 ; Turner. 1954; Magnus & Lammers, 1956; Anand & Dua, 1956 & 1956a). Disturbances in these have als...

There is now sufficient knowledge of the workings of the limbic system to allow experimental manipulation of behaviors anchored in limbic function. While such manipulations have traditionally involved lesions, stimulation or pharmacological approaches, it has become plausible to use gene transfer technology to alter patterns of gene expression in the nervous system. In this review, I consider w...

SINCE its initial description,' transseptal left heart catheterization has been increasingly used as a diagnostic and a research technic. While refinements in instrumentation have emerged 2, 3 the method of septal puncture has remained unchanged. The original description of septal puncture required that the catheter and needle assembly be positioned in the right atrium at a point near the junct...

replaced by oat-shaped cells, appearing identical to those seen in anaplastic bronchial carcinoma’; no tumour was found in the lungs or elsewhere. Their third patient had ‘an encapsulated mass at the root of the right lung’, which consisted of fi brotic lymph nodes. Although in 1956 Charatan and Brierley [7] had previously reported patients with a ‘mental disorder associated with primary lung c...