J.D. Bernhard, MD, Division of Dermatology, University of Massachusetts Medical Center, Worcester, MA 01655 (USA) Dear Sir The picture of ‘brownish macules showing a rippled surface’ on the back of the patient with cutaneous amyloidosis reported by Barnadas et al. [1] is striking because the appearance, location and long history of localized pruritus are virtually identical to what is seen in n...

BACKGROUND Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms. OBJECTIVE In order to investigate the possible beneficial effects of t...

Background: Vulvar dermatoses are inflammatory disorders of genital skin causing itch, pain, dysuria and dyspareunia. Objective: To compare the efficacy of two intimate cleansers as adjuvants in the treatment of the two common vulvar dermatoses: Lichen sclerosus (LS) and lichen simplex chronicus (LSC). Method: 32 patients with the diagnosis of LS or LSC initially treated with Mometasone furoate...

Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old...

BACKGROUND Substances extracted from lichens have previously been reported to possess antimicrobial activities against various groups of bacteria, fungi and viruses. Due to the high abundance of Parmelia perlata in the Eastern parts of Nigeria, we decided to explore whether it possesses antiviral activity against some common animal and human viruses. METHODOLOGY The dried and powdered lichen ...

Background: Hailey-Hailey disease (familial benign chronic pemphigus) of the vulva is a rare autosomal dominant dermatosis characterized by malformation of desmosomes and bullae, particularly in intertriginous areas. Cases: We reviewed the cases of 5 women followed at a single academic institution over a period of 17 years. Of the 5 patients, 4 carried a diagnosis of Hailey-Hailey at the time o...

The neurophysiology of itch, the dominant symptom of skin disease, has previously received scant attention. Recent advances in the neurophysiology and molecular basis of itch include the use of microneurography to demonstrate the existence of a subset of itch-dedicated afferent C neurons distinct from neurons which transmit pain; use of functional positron emission tomography (PET) and magnetic...

BACKGROUND A large number of pathophysiological mechanisms are regulated by microRNAs (miRNAs), which represent a new class of posttranscriptional regulators of gene expression. To date, little is known about their role in oral lichen planus (OLP), a chronic inflammatory mucocutaneous disease of unknown etiology which is being discussed as a potentially premalignant condition of oropharyngeal c...

To evaluate the impact of only free dermatology clinic in Richmond, VA, a retrospective analysis was conducted patients seen at Crossover Health Ministry from December 2020 to 2021. Data extracted eClinicalWorks and de-identified patient data collected. 50 uninsured immigrant were over 62 visits by dermatologists with study range 13 83 years age (mean = 40.5 years, median 39 years), 30% pediatr...

OBJECTIVE(S) The ongoing increasing antibiotic resistance is one of the biggest challenges faced by global public health. The perennial need for new antimicrobials against a background of increasing antibiotic resistance in pathogenic and opportunistic microorganisms obliges the scientific community to constantly develop new drugs and antimicrobial agents. Lichens are known prolific sources of ...