In this immunocytochemical study, heterogeneity in the storage of gonadotropins in the sheep fetus was investigated. LH cells were first detected at 50 days of gestation, whereas FSH and LH-FSH cells were observed from Day 89 on; no gonadotropes containing ACTH were observed. LH cell percentage increased for both sexes between 99 and 120 days of gestation (from 2.8 +/- 0.1 to 4.0 +/- 0.3), rema...

Ovarian cancer is the most lethal gynecological malignancy affecting American women. The gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), have been implicated as growth factors in ovarian cancer. In the present study, pathways activated by FSH and LH in normal ovarian surface epithelium (OSE) grown in their microenvironment were investigated. Gonadotropins increas...

The present study was carried out to characterize the spontaneous release of LH and FSH from the pituitary gland of infant rats in an in vitro system. In addition, the responsiveness of their pituitary glands to synthetic LHRH in vitro was examined. Wistar-Imamichi male and female rats, aged between 1 and 21 days and androgenized female rats at 7 and 21 days of age were used. One-day-old female...

It is well known that majority of patients with collagen diseases are women and that collagen diseases take turn for the worse or the better when the secretion of sex hormones changes greatly at menarche, pregnancy, delivery or menopause. These facts suggest that sex hormones are involved in the pathophysiology of collagen diseases. In the present study, the responses of plasma luteinizing horm...

BACKGROUND Most mammals are seasonal breeders whose gonads grow to anticipate reproduction in the spring and summer. As day length increases, secretion increases for two gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). This response is largely controlled by light. Light effects on gonadotropins are mediated through effects on the suprachiasmatic nucleus and respon...

Objective: To compare Dehydroepiandrosterone Sulfate to Free Testosterone (DHEAS/FT) and Luteinizing Hormone to Follicular Stimulating Hormone (LH/FSH) ratios in Polycystic Ovarian Syndrome (PCOS) women. Material and Methods: The present study was done in the Department of Biochemistry in collaboration with Department of Obstetrics and Gynaecology in which 30 PCOS cases and 30 ages matched heal...

Plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations were measured before and after intravenous luteinising hormone-releasing hormone (LH-RH) in 33 boys with growth delay. Eighteen were prepubertal and 15 pubertal. Basal LH and FSH levels were low in both groups with mean increments after LH-RH of 3.2 +/- 0.8 U/l (mean +/- SEM) and 2.6 +/- 0.4 U/l respectively i...

Basal levels of sex steroids, and the responses of LH and FSH to LH-RH were studied in twenty-five female patients with Cushing's syndrome (17 Cushing's disease and 8 adrenocortical adenoma). Only two patients had a regular menstrual cycle. Amenorrhea or oligomenorrhea had been of long duration in the other cases except for three postmenopausal patients. In patients with Cushing's disease, basa...