نتایج جستجو برای: lh

تعداد نتایج: 17019  

2018
Eva Sipos Nikoletta Dobos David Rozsa Klara Fodor Gabor Olah Zsuzsanna Szabo Lorant Szekvolgyi Andrew V Schally Gabor Halmos

Introduction Uveal melanoma (UM) is the most common primary intraocular malignancy with very poor prognosis. Conventional chemotherapy only rarely prolongs the survival, therefore patients require novel treatment modalities. The discovery of specific receptors for hypothalamic hormones on cancer cells has led to the development of radiolabeled and cytotoxic hormone analogs. Materials and meth...

2010
V. Liu Andrew V. Schally Debra Hawes Shigang Xiong Laden Fazli Martin Gleave Susan Groshen Frank Brands Juergen Engel Jacek Pinski

Download pose: In addition to their expression on pituitary cells, receptors for luteinizing hormone-releasing ne (LH-RH) are found on most prostate cancer cells. These tumoral LH-RH receptors mediate the cytotoxic effects of LH-RH analogs and are potential therapeutic targets. Although pituitary LH-RH ors are downregulated following prolonged exposure to LH-RH agonists, there is no evidence th...

Journal: :The Journal of clinical endocrinology and metabolism 2008
Mark A Lawson Sonia Jain Shelly Sun Ketan Patel Pamela J Malcolm R Jeffrey Chang

CONTEXT In women with polycystic ovarian syndrome (PCOS), the relationship of insulin to LH secretion and responses to GnRH remains unresolved. A rigorous analytical examination of this relationship has not been performed. OBJECTIVE Our objective was to determine the relationship of basal LH secretion and responses to GnRH, insulin, and other endocrine variables in normal and PCOS women. DE...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده کشاورزی 1392

هدف از پژوهش کنونی بررسی اثر کیس پپتین-10 بر تراوش هورمون لوتئینه کننده (lh) در بزهای ماده آنستروس بود. آزمایش با استفاده از 5 ماده بز (5-4 ساله) در فصل آنستروس انجام شد. گامه آنستروس با اندازه گیری پروژسترون 10 و 20 روز قبل از تزریق کیس پپتین تایید شد. پنج بز، یک تزریق درون سیاهرگی سالین (2 میلی لیتر) به عنوان گروه کنترل دریافت کردند و همان بزها یک ساعت بعد کیس پپتین (1 میکروگرم بر کیلوگرم) به...

Journal: :The American journal of physiology 1997
Steven M Pincus Johannes D Veldhuis Thomas Mulligan Ali Iranmanesh William S Evans

We evaluated an apparent distinction between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) dynamics: visually, it appears that the pattern of serum concentrations of FSH is more irregular than that of LH in younger human females. We studied healthy humans, with LH and FSH serum samples obtained every 10 min for 24 h. Three groups were studied: 24 young females [8 early follicu...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2009
Daniel M Keenan Johannes D Veldhuis

The mechanisms by which aging progressively depletes testosterone (Te) availability in the male are unknown. Accordingly, the objective was to estimate brain gonadotropin-releasing hormone (GnRH) outflow (release and action), which cannot be observed directly, on the basis of downstream effects on pituitary luteinizing hormone (LH) secretion. LH, in turn, feeds forward on (stimulates) gonadal T...

Journal: :Human reproduction 2002
Jan Tesarik Carmen Mendoza

BACKGROUND The role of exogenous LH supplementation in ovarian stimulation is a matter of debate. Here we evaluate the impact of exogenous LH on oocyte yield and developmental competence in an oocyte donation programme. METHODS Oocyte donors were randomized (computer-generated randomization list) to groups stimulated with FSH alone or with a combination of FSH and LH after pituitary down-regu...

Journal: :The Biochemical journal 1990
P A van der Merwe R P Millar J S Davidson

Using permeabilized gonadotropes, we examined whether Ca2(+)-stimulated luteinizing-hormone (LH) exocytosis is mediated by the Ca2(+)-activated phospholipid-dependent protein kinase (protein kinase C). In the presence of high [Ca2+]free (pCa 5), alpha-toxin-permeabilized sheep gonadotropes secrete a burst of LH and then become refractory to maintained high [Ca2+]free. The protein kinase C activ...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2004
Daniel M Keenan Johannes D Veldhuis

The present study extends a recent composite model of in vivo interglandular signaling to assess the impact of age on 1) nonequilibrium exchange among diffusible and protein-bound testosterone (Te); 2) elimination of total and free Te; 3) basal and pulsatile Te secretion (sec); 4) the implicit feedforward function mediating luteinizing hormone (LH) concentration (con) drive of instantaneous Te ...

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