OBJECTIVE To explore the relationship between α-synuclein pathology and mitochondrial respiratory chain protein levels within single substantia nigra neurons. DESIGN We examined α-synuclein and mitochondrial protein expression in substantia nigra neurons of 8 patients with dementia with Lewy bodies, 5 patients with Parkinson disease, and 8 control subjects. Protein expression was determined u...

Visual hallucinations are a common, distressing, and disabling symptom of Lewy body and other diseases. Current models suggest that interactions in internal cognitive processes generate hallucinations. However, these neglect external factors. Pareidolic illusions are an experimental analogue of hallucinations. They are easily induced in Lewy body disease, have similar content to spontaneous hal...

This paper reports findings from a case study that investigated the Chinese reading strategies of English speaking learners of Chinese as a Foreign Language (CFL). We focused on CFL learners’ reading of different genres in two different formats, paper-based format and computer-based hypertext format (henceforth hypertext format). Since Chinese characters are categorized in deep orthography, whi...

A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting of different concentrate feeder designs: a control feeder with 4 feeding spaces (CF), a feeder with less concentrate capacity (CFL), and a single-space feeder with lateral protections (SF). Each p...

OBJECTIVE To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS Patients >60 years of age with dementia who had undergone 123I-FP-CIT imaging in research studies and who had donated their brain tissue to th...

The actin filament severing protein cofilin-1 (CFL-1) is required for actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-dependent sorting of secretory proteins at the trans-Golgi network (TGN). How these proteins interact and activate the pump to facilitate cargo sorting, however, is not known. We used purified proteins to assess interaction of the cytoplasmic domains of SPCA1 wit...

BACKGROUND This study was part of a Phase 3 program treating crow's feet lines (CFL) with onabotulinumtoxinA. OBJECTIVE To evaluate the efficacy and safety of onabotulinumtoxinA treatment of CFL. METHODS This multicenter, double-blind, placebo-controlled, 5-month study randomized subjects with moderate-to-severe CFL (maximum smile) to onabotulinumtoxinA (24 U; n = 222) or placebo (n = 223)....

For more than a decade, researchers have refined criteria for the diagnosis of dementia with Lewy bodies (DLB) and at the same time have recognized that cognitive impairment and dementia occur commonly in patients with Parkinson disease (PD). This article addresses the relationship between DLB, PD, and PD with dementia (PDD). The authors agreed to endorse “Lewy body disorders” as the umbrella t...

The spectrum of meson and diquark excitations of the color–flavor locked (CFL) phase of dense quark matter is considered in the framework of the Nambu – JonaLasinio model. We have found that in this phase all Nambu–Goldstone bosons are realized as scalar and pseudoscalar diquarks. Other diquark excitations are resonances with mass value around 230 MeV. Mesons are stable particles in the CFL pha...

The ground state of three flavor quark matter at asymptotically large density is believed to be the color-flavor-locked (CFL) phase. At nonasymptotic density the effect of the nonzero strange quark mass cannot be neglected. If the strange quark mass exceeds m(s) approximately m(u)(1/3)delta(2/3), the CFL state becomes unstable toward the formation of a neutral kaon condensate. Recently, several...