Aberrant microglial responses contribute to neuroinflammation in many neurodegenerative diseases, but no current therapies target pathogenic microglia. We discovered unexpectedly that the antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS), as well as in kainic acid-induced excitot...

background: toxoplasma gondii is an obligatory intracellular protozoan parasite on which studies are pending regarding production of vaccine. to date, the production of human vaccine has not been successful where approximately one third of the world’s population is thought to be infected with t. gondii. objectives: the present study was designed to compare the electrophoretic patterns of t. gon...

in this study morphological characterization of leukocyte and erythrocyte were investigated in central asian tortoise (testudo horsfieldii) in iran. 7 males and 7 females were used in this study. erythrocyte and leukocyte morphology were described using wright´s technique. the sizes of erythrocyte and their nuclei were measured using an ocular micrometer under objective lenses (100x). results o...

background: despite the efforts to enhance hygiene education and personal hygiene and use of antibiotics and vaccination, infectious diseases remain the second cause of mortality worldwide. vaccination is one of the greatest medical achievements in the prevention of mortality and morbidity, which has decreased treatment costs. this study aimed to compare the complications caused by pentavalent ...

immunization is today one of the safest, most cost-effective, and powerful means of preventing deaths and improving lives. over the years, all countries of the world have incorporated an increasingly broad immunization agenda in their public health interventions. immunization programmes are now routinely reaching over 80 percent of children under one year of age. iran and turkey with a populati...

high morbidity and mortality of influenza virus infection makes it an important disease world-wide. mouse is a very well-studied animal model for this disease with similar manifestation to human disease. it would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. cell mediated immunity (proliferativ...

tm purpose of this study is 10 determine the effect of mothers' knowledge on the treatment quality of their   children immunization in health centers of the ministry of health , and medical education in tehran in 1994 .   the samples were 150 mothers who went to health centers to immunize their children .   the subjects were selected randomly and data - gathering was accomplished through a...

background: the study aimed to examine the association between human leukocyte antigen (hla) class ii allele frequencies and breast cancer in iranian women. methods: a total of 100 patients with pathologically proven breast cancer who referred to cancer institute were randomly selected and compared with a group of age matched healthy blood donors (n = 80). hla class ii alleles were determined b...

conclusions respiratory distress is more common in eos whereas jaundice, fever and seizure are more likely to be observed in los infants. considering the results, clinical manifestations should be regarded as an important part of early diagnosis of sepsis. objectives the aim of this study was to evaluate, record and rank the clinical manifestations and lab data of neonates with clinical sepsis....