acute myeloid leukemia (aml) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (mrds) which are resistant to current chemotherapeutic regimens and mediate disease relapse. current therapeutic vaccine strategies have d...

leukemia is a neoplastic disease with early oral and periodontal manifestations such as ulceration, infection, bleeding and gingival hyperplasia. this paper describes a 39-year-old pregnant woman with a diagnosis of acute myelomonocytic leu-kemia (aml), with gingival enlargement in the upper and lower jaws. a gingival biopsy was performed, followed by a complete blood count and peripheral blood...

Nano Cell Cycle Checkpoint Inhibitors In article number 2300736, Daishun Ling, Fangyuan Li, and co-workers demonstrate that ultra-small iron oxide nanoparticles (IONPs) can serve as a selective nano cell cycle checkpoint inhibitor (NCCI) to catalyze the intracellular H2O2 into abundant ·OH, cleave heat shock protein 90 (Hsp90), thus induce degradation of client ATR/CHK1, leading dysfunction G2/...

Background and Objective: Vascular endothelial growth factor (VEGF) is a cytokine which is overexpressed in many malignant cancers including leukemia. VEGF plays an important role in tumor invasion and metastasis. Determination of the pattern of VEGF expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

Background: In various cancers, Ganoderic Acid A (GAA), an active triterpenoid derived from Ganoderma lucidum, has been proved to show potent anti-tumor effects. However, the possible impacts of GAA on the human leukemia cell line (Nalm-6) are not fully elucidated. Therefore, this research aimed to study the antineoplastic effect of GAA on Nalm-6 cells. Materials and Methods: In this laborator...

Leukemia, a type of blood cancer that originates in the bone marrow, is characterized by uncontrolled growth abnormal cells, which disrupt normal functioning cells. Chimeric antigen receptor (CAR) T-cell treatment, form immunotherapy, utilizes genetically modified T cells to specifically target and eliminate This treatment has shown promising results for leukemia patients who are unresponsive c...

Leukemia is a malignant disease and belongs in broader sense to Cancers. There are many types of leukemia, each which requires specific treatment. almost one-third all cancer deaths children young people. The most common type leukemia acute lymphoblastic (ALL). In this paper, new approach implanted on ALL database. For the method wavelet transform used for feature extraction, gray level co-occu...

background : according to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. this study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. methods :we conducted a web-based search for all peer ...

Abstract Objectives The B cell lymphoma-2 (BCL-2) protein group is essential for regulating apoptosis. BCL2L13 harbors all BH domains present in the BCL-2 family addition to a BHNo domain comprising 250 amino acids at its C-terminal. highly expressed AML and involved We investigated possibility of discovering as treatment target acute leukemia. Methods reduced expression Mono Mac 6 (MM6) cells ...