BACKGROUND Rare mutations in the leptin (LEP) gene cause severe obesity. Common polymorphisms of LEP have been associated with obesity, but their association with cardiovascular disease has been little studied. We have examined the impact of both common and rare polymorphisms of the LEP gene on blood pressure (BP), subclinical atherosclerosis as measured by carotid intima-medial thickness (CIMT...

Craniopharyngioma (CP) is a benign tumor with high rate of obesity and frequent recurrence. Moreover, the role leptin/leptin receptors axis in prognosis CP still unknown. Plasma leptin concentration mRNA expression were assessed patients CP. association between axis, weight-related outcomes, progression-free survival (PFS) explored patients. Leptin overexpressed tissue compared to normal brain ...

Leptin is a confirmed breast cancer susceptibility gene. However, published studies reported mixed results. This meta-analysis was conducted to systematically get a more accurate estimation of the association between the Leptin (-2548G/A) gene polymorphism and breast cancer risk. To assess the effect of Leptin (-2548G/A) gene polymorphism on breast cancer susceptibility, we searched PUBMED, ISI...

multiple sclerosis (ms) is a multifactorial disease (caused by both environmental and genetic features) that could results from a demyelination of the myelin sheath. subsequently, it leads to many scars or lesions in different places within the central nervous system. the symptoms that occur depend on the site and rigorousness of the lesions and this is why people with ms experience different s...

Leptin is known as the adipose peptide hormone. It plays an important role in the regulation of body fat and inhibits food intake by its action. Moreover, it is believed that leptin level deductions might be the cause of obesity and may play an important role in the development of Type 2 Diabetes Mellitus (T2DM), as well as in cardiovascular diseases (CVD). The Leptin Receptor (LEPR) gene and i...

Leptin receptor (OBR) is a member of the class I cytokine receptor family. It signals mainly via the JAK/STAT pathway and plays an important role in regulating body energy storage and metabolism. This study was designed to investigate the effects of the OBR gene on chicken growth and body composition. Broiler lines selected divergently for or against abdominal fat were used. Primers for the exo...

osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (sns) and bone metabolism. leptin has been shown to regulate bone formation and bone resorption via the sns. however, the effect of sns on leptin signaling has not been clearly understood. in the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

The objective of this study was to search for single nucleotide polymorphism (SNP)-type polymorphisms in the dopamine D1 receptor in West Azerbaijani native chicken and look for their association with egg production and body weight traits of chickens by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). For this purpose 180 blood samples were taken from nativ...