results tst was positive in 198 (60.4%) health care workers out of 328. likelihood of positive tst among hcws increased in nurses (or = 4.617, 95% ci = 1.181-18.054, p = 0.028), increasing working experience (or = 1.178, 95% ci = 1.131 - 1.226, p < 0.001), and history of exposure to patients with tb (or = 9.035, 95% ci = 4.018 - 20.315, p < 0.001). age, gender and bcg vaccination scar were not ...

aeroallergens continue to have a key role in the pathogenesis of asthma and allergic diseases and have recently received increased attention in medical research throughout the world. the prevalence of aeroallergens vary in different regions, depending on the type of climate. the aim of the present study was to determine prevalence of the sensitivity to aeroallergens among patients with asthma a...

The mechanisms linking the immune response to cutaneous and mucosal leishmaniasis (CL and ML, respectively) lesions and the response to treatment are incompletely understood. Our aims were to prospectively assess, by quantitative reverse transcription-PCR, the levels of mRNA for gamma interferon, tumor necrosis factor alpha, interleukin-10 (IL-10), IL-4, and IL-13, as well as the presence of T ...

Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leishmania antigens injected intraderm...

Objective(s): To design a multivalent DNA vaccine encoding the most immunogenic regions of the Leishmania major antigens including TSA (Thiol-specific antioxidant protein), LmSTI1 (Leishmania major stress-inducible protein1), LACK (Leishmania homologue of receptors for activated C Kinase), and KMP11 (kinetoplastid membrane protein-11) on BALB/c mice.M...

We conducted a longitudinal study in an endemic area for visceral leishmaniasis (VL) in eastern Sudan to compare the epidemiology and clinical spectrum of Leishmania donovani infection in two populations differing in ethnic background and duration of residence in the area. The study took place in two villages from April 1994 to April 1996. In Um-Salala village, which is inhabited by members of ...

LTB 131, a 12 year old boy, came to the clinic with a typical leishmania ulcer on his right leg (20mm in diameter with a raised rolled edge) present for 6 months. Neither giemsa stained smears nor hamster inoculation showed evidence of parasites. Histology was compatible with the clinical diagnosis. The leishmanin test (using a 30ju,g dose of protein) was negative in 1980,1981, twice in 1983 (a...

OBJECTIVE To document the frequency of Leishmania donovani infection at community level in a highly endemic region in southeastern Nepal, and to assess socioeconomic and environmental risk factors. METHODS A random cross-sectional population survey was held in two visceral leishmaniasis (VL) foci in Morang District in April to May 2003, enrolling individuals 2 years or older and residing in t...