background: although pentavalent antimony compounds are used as antileish-manial drugs but they are associated with limitations and several adverse complica-tions. therefore, always effort to find a new and effective treatment is desired. in this study, the effect of zno nanoparticles with mean particle size of 20 nanome-ters (nm) on leishmania major promastigotes and amastigotes was evaluated....

background: the aim of this study was to investigate the effects of leishmania major infection on the induction of oxidative stress in skin and lung of female mice. methods: balb/c mice were randomly divided into the control and experi-mental groups. the experimental groups were subcutaneously infected with in-oculums promastigotes of l. major . the animals were sacrificed at 20, 40, 60, 90 and...

background: leishmaniasis is a parasitic disease caused by different species of leishmania parasites with a wide range of clinical manifestations . antimonial compounds such as meglumine antimoniate (glucantime) are the first line drugs for the treatment of leishmaniasis. however, according to reports of the drug resistance of parasites, the efficacy of antimonial compounds is low. the atp-bind...

background: cutaneous leishmaniasis (cl) is one of the most important health problems in different regions of iran that occurs both in zoonotic and anthroponotic forms in different foci of iran. the khuzistan province, located in the south west of iran in vicinity of the persian gulf, is one of the oldest susceptible foci for cl in iran. objectives: due to the lack of information about the cond...

We report a transient expression transfection system in Leishmania enriettii. A hybrid gene containing an intergenic region of the alpha-tubulin cluster and the bacterial chloramphenicol acetyltransferase (CAT; EC 2.3.1.28) gene is expressed after transfection of L. enriettii with the hybrid plasmid. The expression of the CAT gene is dependent on the presence of sequences from the alpha-tubulin...

In the past decade in Morocco, there has been a reactivation of zoonotic cutaneous leishmaniasis (ZCL) foci with an unusual long outbreak episode. The aims of this review article were to update our knowledge of this disease in Morocco, to compare the situation with that prevailing in the other countries of the Maghreb region and to highlight factors that could be responsible for the current sit...

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.

background: protozoa related to trypanosome family including leishmania , synthesize enzymes to escape from drug therapy. one of them is ptr1 that its enzymatic activity is similar to dihydrofolate reductase (dhfr). dihydrofolate reductase - thymidylate synthase has a major role in dna synthesis, if it is inhibited, the result would be the death of parasite. since ptr1 activity is similar to dh...