STUDY OBJECTIVE Absolute lymphocytopenia is recognised as an important hallmark of the immune response to severe infection and observed in patients with Legionnaires' disease. To explore the immune response, we studied the dynamics of peripheral blood lymphocyte subpopulations in the acute and subacute phase of LD. METHODS AND RESULTS EDTA-anticoagulated blood was obtained from eight patients...

In three pediatric patients with necrotizing lymphadenitis, cytosol aminopeptidase activity (c-AP; EC 3.4.11.1) in serum was markedly increased to 509, 417, and 191 U/L, respectively (normal range 25-60 U/L). Lactate dehydrogenase (LD; EC 1.1.1.27) was also increased, with LD-3 predominating. The increased concentrations of c-AP and LD presumably originated from the destruction of infected, act...

In many applications counter is used to divide input clock to produce output, the frequency of the output is the divide by N times of the input clock frequency. Due to these reasons ripple counters can be used as frequency dividers to reduce a high clock frequency down to a more usable value for use in digital clocks and timing applications. In many applications such as ultra low power digital ...

objectives: attention deficit hyperactivity disorder (adhd) along with learning disorder (ld) is one of the most important child and adolescent psychiatric disorder. they are most often seen comorbidly in patients. our study seeks to examine the relationship between adhd and ld in our sample. method: thirty boys suffering from adhd, as diagnosed by certified child and adolescent psychiatrists u...

Supernatants of cultured human thymic nonlymphoid cells were assayed for granulopoietic factors using cultures of low density bone marrow mononuclear cells (LD-BMMC). Thymic nonlymphoid cell-conditioned medium (TNLC-CM) supported vigorous myeloid colony growth of LD-BMMC. and of LD-BMMC depleted of T lymphocytes and/or monocytes. Colony stimulating activity (CSA) in TNLC-CM was abrogated by a h...

Clonotype-positive (1B2+) T cells from 2C T cell receptor (TCR) transgenic mice were used to define the role of CD8 molecules in the induction phase vs. the effector phase of the primary response to class I alloantigens. Three main findings are reported. First, in the presence of exogenous lymphokines, resting CD8+ 2C cells gave strong proliferative responses to two alloantigens, Ld and Kbm11. ...

Pretransplantation donor-specific transfusion (DST) can enhance allograft survival in man and animals. However, due to the lack of a specific marker to identify donor-reactive cells in vivo in man and normal (nontransgenic) animals, the underlying mechanism remains unknown. In this study, we use 2CF1 transgenic mice expressing a transgenic T-cell receptor (TCR) specifically recognizing Ld, a ma...

Const i tut ive equations appropriate t o the rate-dependent p l a s t i c deformation of an i so t rop ic mater ials a re developed. The method used i n the der iva t ion cons i s t s of the inclusion of the appropriate r a t e of deformation var iab le i n the func t iona l d e f i n i t i o n of the y ie ld surface and the requirement t h a t the s t a t e p i n t remain on t h i s y ie ld s...