Normal contraction of cardiac muscle requires a coordinated cellular mechanical response to the electric pacemaker signal that begins in the sinoatrial node and spreads through the conduction system and ultimately across the ventricular myocardium via gap junctions. In ventricular myocytes, depolarization by the action potential causes clusters of L-type calcium channels (LCCs) to open, allowin...

Introduction In the heart, excitation-contraction coupling (ECC) is a sequence of events that begins with membrane depolarization by an action potential (AP), followed by activation of voltage-gated Ca channels in the surface membrane, initiation of Ca release from the SR Ca store by CICR, and the resulting contraction. Most of our knowledge of the mechanistic details of ECC originates from stu...

Introduction In the heart, excitation-contraction coupling (ECC) is a sequence of events that begins with membrane depolarization by an action potential (AP), followed by activation of voltage-gated Ca channels in the surface membrane, initiation of Ca release from the SR Ca store by CICR, and the resulting contraction. Most of our knowledge of the mechanistic details of ECC originates from stu...

land cover is one of basic data layers in geographic information system for physical planning and environmentalmonitoring. digital image classification is generally performed to produce land cover maps from remote sensing data,particularly for large areas. in the present study the multispectral image from irs liss-iii image along with ancillary datasuch as vegetation indices, principal componen...

Abstract. Over past decades, a lot of global land-cover products have been released; however, these still lack map with fine classification system and spatial resolution simultaneously. In this study, novel 30 m for the year 2015 (GLC_FCS30-2015) was produced by combining time series Landsat imagery high-quality training data from GSPECLib (Global Spatial Temporal Spectra Library) on Google Ear...