نتایج جستجو برای: latent tuberculosis
تعداد نتایج: 149965 فیلتر نتایج به سال:
Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-gamma release ass...
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M. tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using interferon-γ release assays (IGRAs) or the tuberculin-skin-test (TST). In clinical practice, IGRAs and the TSTs have failed to distinguish between active tuberculosis and LTBI and their predictive value to identify ...
A recently conducted study on tuberculosis contact investigations in six Sydney tuberculosis clinics - that together managed 59% of all tuberculosis cases in NSW from January 2000 to December 2009 - found that the prevalence of tuberculosis among contacts was comparable to other low-incidence settings. However, only 9% of contacts with latent tuberculosis infection received treatment. This pape...
BACKGROUND Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy. OBJECTIVES We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda. METHODS We analyzed...
It is believed that persistence of small populations of Mycobacterium tuberculosis in hosts underlies latent tuberculosis. Very little is known about the morphological and physiological nature of tubercle bacilli in latent TB. It is under discussion whether and how tubercle bacilli adapt to latent state and remain alive in face of damaging stressful conditions such as antibiotics and host immun...
A tuberculosis (TB) model with lost sight and multiple latent classes is considered and studied. We derive the basic reproduction ratio $mathcal R_0$. There is always a globally asymptotically stable equilibrium state. Depending on the value of $mathcal{R}_0$, this state can be either endemic ($mathcal{R}_0> 1$), or infection-free ($mathcal{R}_0leq 1$). The global asymptotic stability of ...
Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models a...
OBJECTIVE To identify the incidence of and risk factors for tuberculosis in people living with HIV (PLHIV). DESIGN Observational, prospective cohort study. METHODS A total of 2069 HIV-infected patients was observed between July 2007 and December 2010. The Kaplan-Meier method was used to estimate the probability of survival free of tuberculosis, and Cox regression analysis to identify risk f...
Mycobacterium tuberculosis-latent bacilli are microorganisms that adapt to stressful conditions generated by the infected host against them. By slowing metabolism or becoming dormant, they may counterbalance these conditions and appear as silent to the immune system. Moreover, the dynamic turnover of the infected cells provokes a constant reactivation of the latent bacilli when the environmenta...
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