OBJECTIVE The aim of this study was to measure the effects of endotracheal intubation on innate immune response within the pig laryngeal mucosa. STUDY DESIGN Prospective controlled basic science study. SETTING The animal experiments and analyses were conducted at the University of Bristol. SAMPLES AND METHODS Eighteen pigs, matched at the major histocompatibility complex (MHC), were used ...

BACKGROUND The pathogenesis of ulcerative colitis is unclear, but cytotoxic T lymphocytes infiltrating the mucosa have been implicated in mucosal damage. The Fas ligand (FasL), expressed on cytotoxic T lymphocytes, induces apoptosis in cells expressing Fas. AIM To analyse FasL expression in affected colonic mucosa to ascertain Fas-FasL interaction in ulcerative colitis. METHODS FasL mRNA wa...

St. John's wort oil is one of the herbal product which used for therapeutic purposes. To investigate effects Wort on irritated gastrointestinal mucosa and liver. The study based experimental animal trials. 21 healthy swiss albino mice were randomly divided into three groups: control group, group-2, group-3. methotrexate (20 mg/kg) was given intraperitoneally as a single dose 1st day to group-2 ...

Asthma needs continuous treatment often for years. In humans, some drugs are administered via aerosol, therefore they come in contact with both respiratory and olfactory mucosa. We explored the possibility that antiasthma corticosteroid treatment could influence the olfactory function by passage through the nose. A group of mice was exposed twice daily for 42 days to fluticasone propionate aero...

Objective: To study the literature on role of B-lymphocytes and plasma cells in pathogenesis Crohn’s disease (CD) ulcerative colitis (UC). Materials methods: We analyzed 86 sources from Scopus, Web Science, Google scholar, PubMed databases, as well those that are freely available Google. Results. CD UC a serious public health problem due to their wide prevalence, objective difficulties treatmen...

A 65‐year‐old woman had mild paroxysmal pain in the upper abdomen for 3 years. A colonic endoscopy performed in Taizhou People’s Hospital found a cylindrical elongated, worm‐like polyp with a narrow base in the cecum [Figure 1a]. The surface mucosa of the polyp showed multifocal erosion [Figure 1b]. No diverticulum, other polyps or mass were found during endoscopy. She subsequently underwent en...

Immunohistological analysis of the cellular composition of the small intestinal mucosa in a group of untreated and treated coeliac patients and non-coeliac control subjects was performed using monoclonal antibodies and an immunoperoxidase technique. A characteristic cellular distribution was observed within the normal mucosa. The intraepithelial and lamina propria compartments were occupied mai...

TB remains a very significant global health burden. There is an urgent need for better tools for TB control, which include an effective vaccine. Bacillus Calmette-Guérin (BCG), the currently licensed vaccine, confers highly variable protection against pulmonary TB, the main source of TB transmission. Replacing BCG completely or boosting BCG with another vaccine are the two current strategies fo...

The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in mounting protective immune responses to pathogens and, as such, to play key roles in regulating intestinal immune homeostasis. The characterization ...

Endocrine cells of gastric and gut mucosa are commonly thought to be present only within mucosal glands. In a previous report, we described argyrophilic cells in the lamina propria in 40% of surgical gastric specimens, using light microscopy. All these patients had chronic gastritis. Argyrophilia, however, is a non-specific reaction which could occur in other than endocrine cells. The present s...