نتایج جستجو برای: laea
تعداد نتایج: 98 فیلتر نتایج به سال:
Recent estimates of the global burden of fungal disease suggest that that their incidence has been drastically underestimated and that mortality may rival that of malaria or tuberculosis. Azoles are the principal class of antifungal drug and the only available oral treatment for fungal disease. Recent occurrence and increase in azole resistance is a major concern worldwide. Known azole resistan...
Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the form of allergic, and life-threatening invasive infections. The success of A. fumigatus as a pathogen is unique among close phylogenetic relatives ...
Caffeic acid (3,4-dihydroxycinnamic acid, 12 mM) added to a fat-based growth medium reduces >95% of aflatoxin production by Aspergillus flavus NRRL 3357, without affecting fungal growth. Microarray analysis of caffeic acid-treated A. flavus indicated expression of almost all genes in the aflatoxin biosynthetic cluster were down-regulated, ranging from a log2 ratio of caffeic acid treated and un...
LaeA and VeA coordinate secondary metabolism and differentiation in response to light signals in Aspergillus spp. Their orthologs, ChLae1 and ChVel1, were identified in the maize pathogen Cochliobolus heterostrophus, known to produce a wealth of secondary metabolites, including the host selective toxin, T-toxin. Produced by race T, T-toxin promotes high virulence to maize carrying Texas male st...
Aspergillus fumigatus is an opportunistic pathogen that causes 90% of invasive aspergillosis (IA) due to Aspergillus genus, with a 50-95% mortality rate. It has been postulated that certain virulence factors are characteristic of A. fumigatus, but the "non-classical" virulence factors seem to be highly variable. Overall, published studies have demonstrated that the virulence of this fungus is m...
s: (*Denotes student presenting poster) Biochemistry and Metabolism 1. Identification of local and cross-chromosomal biosynthetic gene clusters in filamentous fungi using gene expression data. Mikael R. Andersen 1 , Jakob B. Nielsen 1 , Andreas Klitgaard 1 , Lene M. Petersen 1 , Tilde J. Hansen 1 , Lene H. Blicher 1 , Charlotte H. Gottfredsen 2 , Thomas O. Larsen 1 , Kristian F. Nielsen 1 , Uff...
s * denotes a student presenting the poster 1. *Examining the evolution of the regulatory circuit controlling secondary metabolism and development in Aspergillus Abigail Lind, Jennifer Wisecaver, Timothy Smith, Xuehan Feng, Ana Calvo, Antonis Rokas 1) Biomedical Informatics, Vanderbilt University, Nashville, TN.; 2) Biological Sciences, Vanderbilt University, Nashville, TN; 3) Biological Scienc...
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