Heterogeneity has been recently highlighted as a relevant characteristic of diabetes mellitus. The current classification of diabetes mellitus includes two main types of the disease, i.e. type 1 and type 2 diabetes. The latter is by far the most prevalent one. Nevertheless, there is a significant proportion of subjects with autoimmune diabetes mellitus that are classified as type 2 diabetic pat...

Aims: The objective of this study was to utilize C peptide levels to identify the patients suspected of having latent autoimmune diabetes in adults from clinically diagnosed type 2 diabetics. Methods:100 type 2 DM patients and 100 healthy controls were selected. All patients were assessed for fasting Cpeptide and insulin levels. Patients having C-peptide level<0.7 ng/ml were classified as suspe...

P ositive islet cell–related autoantibody is thought to reflect the process of immune-mediated -cell damage symbolized by the insulitis, but there have been few reports on the pancreas histology of latent autoimmune diabetes in adults (LADA). We report a study of pancreas histology and a longitudinal insulin secretion in a LADA patient. A 50-year-old woman treated with sulfonylurea from the age...

Heterogeneity has been recently highlighted as a relevant characteristic of diabetes mellitus. The current classification of diabetes mellitus includes two main types of the disease, i.e. type 1 and type 2 diabetes. The latter is by far the most prevalent one. Nevertheless, there is a significant proportion of subjects with autoimmune diabetes mellitus that are classified as type 2 diabetic pat...

In 2012, cancer genomics saw the addition of a new phrase to its lexicon: kataegis, Greek for thunderstorm and an apt description for the discovery of localized regions of hypermutation that were revealed when numerous breast cancer genomes were sequenced in a landmark study in Cell. Michael Stratton from the Wellcome Trust Sanger Institute, UK, and fellow co-authors of the study speculated tha...

Star clusters are formed in molecular clouds which are believed to be the birth places of most stars. From recent observational data, Lada & Lada(2003) estimated that only 4 to 7% of the proto-clusters have survived. Many factors could cause this high infant mortality. Galactic tidal forces, close encounters with molecular clouds and shock heating are among the possible causes but they have a l...

We have observed the dark cloud Barnard 68 with SCUBA at 850 µm and with SIMBA at 1.2 mm. The submillimetre and millimetre dust emission correlate well with the extinction map of Alves, Lada, & Lada (2001). The A V /850 µm correlation is clearly not linear and suggests lower temperatures for the dust in the inner core of the cloud. Assuming a model for the temperature gradient, we derive the cl...