Aim: Pulmonary embolism (PE) is the third leading cause of death due to cardiovascular disease. The presence shock or hypotension remains main prognostic clinical marker and date, it only factor that indicates need for aggressive treatment. Most patients with pulmonary are normotensive. Prognostic indicators needed better classify embolism. This study aimed investigate effect lactate level on p...

Lactate is widely measured in critically ill patients as a robust indicator of patient deterioration and response to treatment. Plasma concentrations represent balance between lactate production clearance. Analysis has typically been performed with the aim detecting tissue hypoxia. However, there diverse range processes unrelated increased anaerobic metabolism that result accumulation lactate, ...

INTRODUCTION Since normal or high central venous oxygen saturation (ScvO₂) values cannot discriminate if tissue perfusion is adequate, integrating other markers of tissue hypoxia, such as central venous-to-arterial carbon dioxide difference (PcvaCO₂ gap) has been proposed. In the present study, we aimed to evaluate the ability of the PcvaCO₂ gap and the PcvaCO₂/arterial-venous oxygen content di...

BACKGROUND Metformin is a worldwide accepted biguanide antidiabetic agent, and its effectiveness and benefit have already been well established. Among the side effects of metformin, lactate acidosis is the most problematic because of a high mortality rate, which impedes its use in clinical practice, especially in elderly patients with type 2 diabetes. Aging is associated with a decreased renal ...

The origins of sepsis-induced hyperlactatemia are still imperfectly understood and probably multifactorial, resulting both from an increased production by various tissues through aerobic and anaerobic glycolysis, and from a decreased lactate clearance. In the previous issue of Critical Care, Michaeli and colleagues showed that lactate elevation during mild endotoxemia is due to an increased aer...

This study examines the influence of ascorbic acid pretreatment on ethanol clearance, toxicity, and behavioral impairment after an acute dose of ethanol in humans. Ascorbic acid or a placebo was given to 20 healthy male subjects for 2 weeks before ethanol consumption. The dose of ethanol was 0.95 gm/kg body weight and was consumed during a 2 1/2-hour period. Thirty minutes after ethanol consump...