House mouse (Mus musculus) is a cosmopolitan pest in agricultural facilities, commodity stores and rural urban environments. It regularly controlled by anticoagulant-based baits. Since the number of registered active ingredients limited, producers are trying to develop new formulations with increased tamper-resistance, attractiveness palatability. Reliable economical methods for laboratory scre...

The gentle and careful use of laboratory animals requires specific knowledge on thegeneral biology and the characteristic hallmarks of the used animals and the adequateconsideration of legal requirements, ethical aspects, and scientific guidelines. In thischapter, important topics of laboratory animal science regarding the mouse as laboratoryanimal are addressed. Initially, a br...

Kate McDole is a Group Leader at the MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK. Using mouse embryo as model, Kate's research group studies how mechanical forces can shape complex three-dimensional structures out simple populations cells. We met with to find more about her career, challenges setting up lab during pandemic, and thoughts on mentorship transitioning leader position.

The Mouse Genome Database (MGD) forms the core of the Mouse Genome Informatics (MGI) system (http://www.informatics.jax.org), a model organism database resource for the laboratory mouse. MGD provides essential integration of experimental knowledge for the mouse system with information annotated from both literature and online sources. MGD curates and presents consensus and experimental data rep...

The laboratory mouse is the premier animal model for studying human biology because all life stages can be accessed experimentally, a completely sequenced reference genome is publicly available and there exists a myriad of genomic tools for comparative and experimental research. In the current era of genome scale, data-driven biomedical research, the integration of genetic, genomic and biologic...

The Mouse Genome Database (MGD) is one component of the Mouse Genome Informatics (MGI) system (http://www.informatics.jax.org), a community database resource for the laboratory mouse. MGD strives to provide a comprehensive knowledgebase about the mouse with experiments and data annotated from both literature and online sources. MGD curates and presents consensus and experimental data representa...

The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that distinguish these species. While insertions of transposable elements are responsible for only approximately 0.1% of de novo mutations in humans, th...

The first trial in the developmental phase of the "Performance Evaluation Program" based on the new programs of the International Council for Laboratory Animal Science (ICLAS) was carried out. ICLAS supplied test samples to each diagnostic laboratory for self-assessment of microbiological monitoring methods. We found that 1 mouse serum sample was positive for mouse minute virus and another was ...

conclusions it seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury. results the result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules i...