REM sleep is the most antiepileptic state in the sleep-wake cycle for human generalized epilepsy, yet the neural mechanism is unknown. This study verified the antiepileptic properties of REM sleep in feline generalized epilepsy and also isolated the responsible factors. Conclusions are based on 20 cats evaluated for generalized EEG and motor seizure susceptibility before and after dissociation ...

The neurophysiologic basis of near death experience (NDE) is unknown. Clinical observations suggest that REM state intrusion contributes to NDE. Support for the hypothesis follows five lines of evidence: REM intrusion during wakefulness is a frequent normal occurrence, REM intrusion underlies other clinical conditions, NDE elements can be explained by REM intrusion, cardiorespiratory afferents ...

It is becoming established that the amygdala has a strong influence on arousal state, with most evidence indicating a role in the regulation of rapid eye movement sleep (REM). Electrically activating the central nucleus of the amygdala (CNA) can increase subsequent REM and enhance REM-related phenomena. However, drugs that may be inhibitory to CNA have been typically reported to reduce REM. Thi...

BACKGROUND AND PURPOSE Obstructive sleep apnea (OSA) is more severe during rapid eye movement (REM) sleep than during non-REM sleep. We aimed to determine the features of patients with OSA who experience little REM sleep. METHODS Patients with a chief complaint of sleep-disordered breathing were enrolled. All subjects underwent overnight polysomnography (PSG) and completed questionnaires on s...

Most depressed patients suffer from sleep abnormalities, which are one of the critical symptoms of depression. They are robust risk factors for the initiation and development of depression. Studies about sleep electroencephalograms have shown characteristic changes in depression such as reductions in non-rapid eye movement sleep production, disruptions of sleep continuity and disinhibition of r...

The hypothesized role of rapid eye movement (REM) sleep, which is rich in dreams, in the formation of new associations, has remained anecdotal. We examined the role of REM on creative problem solving, with the Remote Associates Test (RAT). Using a nap paradigm, we manipulated various conditions of prior exposure to elements of a creative problem. Compared with quiet rest and non-REM sleep, REM ...

NARCOLEPSY IS CHARACTERIZED BY THE PRESENCE OF EXCESSIVE DAYTIME SLEEPINESS AND CLINICAL MANIFESTATIONS OF DISSOCIATED RAPID EYE MOVEMENT (REM) sleep including cataplexy, hypnagogic and hypnopompic hallucinations, and sleep paralysis.1 Normal REM sleep is characterized by tonic features, including cortical EEG desynchronization and muscle atonia, and phasic events, including bursts of rapid eye...

We develop methodology which combines statistical learning methods with generalized Markov models, thereby enhancing the former to account for time series dependence. Our methodology can accommodate very general and very long-term time dependence structures in an easily estimable and computationally tractable fashion. We apply our methodology to the scoring of sleep behavior in mice. As current...

ATONIA OF SKELETAL MUSCLES IS ONE OF THE CARDINAL FEATURES OF RAPID EYE MOVEMENT (REM) SLEEP. Superimposed on this atonia is intermittent activity in both axial and limb muscles. REM sleep behavior disorder (RBD) is characterized by excessive motor activity during REM sleep with acting out of dreams.1 The diagnosis of RBD is made by the appearance of elevated submental electromyogram (EMG) tone...